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Small Clinical Trials: Issues and Challenges

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Univ. of Louisville, KY. A report of the Committee on Strategies for Small-Number-Participant Clinical Trials of the Institute of Medicine, on the issues and challenges of conducting clinical trials with small numbers of participants. Discusses the design and implementation of future research projects for efficiency. Softcover.

Author(s): Committee on Strategies for Small-Number-Participant Clinical Research Trials, Board on Health Sciences Policy
Series: Compass Series
Edition: 1
Publisher: National Academies Press
Year: 2001

Language: English
Pages: 222

Cover......Page 1
Front Matter......Page 2
Reviewers......Page 8
Preface......Page 10
Contents......Page 12
Executive Summary......Page 16
1 Introduction......Page 27
2 Design of Small Clinical Trials......Page 35
3 Statistical Approaches to Analysis of Small Clinical Trials......Page 75
4 General Guidelines......Page 106
References......Page 109
Appendix A Study Methods......Page 120
Appendix B Glossary of Statistical and Clinical Trials Terms......Page 145
Appendix C Selected Bibliography on Small Clinical Trials......Page 192
Appendix D Committee and Staff Biographies......Page 216