Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin. Showing how these proteins are employed in micro and nano drug delivery systems, their use in pre-clinical and clinical trials, and closing with chapter on sustainability- driven innovation in the pharma industry, this book is ideal for graduates and researchers in biomaterials science and pharmaceutical science.
Author(s): Elia Bari, Sara Perteghella, Maria Luisa Torre
Publisher: Royal Society of Chemistry
Year: 2020
Language: English
Pages: 241
City: London
Cover
Silk-based Drug Delivery Systems
Preface
Acknowledgements
Contents
Chapter 1 - Micro and Nano-drug Delivery Systems
1.1 Introduction
1.2 Materials Used for Micro or Nano-drug Delivery Systems Preparation
1.2.1 Inorganic Materials
1.2.2 Organic Materials
1.3 Methods for Micro and Nano-drug Delivery Systems' Preparation and Drug Loading
1.3.1 Physical and Chemical Methods for the Production of Micro/Nanoparticles
1.3.2 Factors that Influence the Drug Loading into Micro/Nanoparticles
1.4 Therapeutic Applications of Micro and Nano-drug Delivery Systems
1.4.1 The Importance of Drug Targeting
1.4.2 Delivery and Targeting of RNA
1.4.3 Micro/Nano-drug Delivery Systems and Vaccination
1.4.4 Micro/Nanosystems for Skin Drug Delivery
1.4.5 Intraocular Drug Delivery by Micro/Nano-drug Delivery Systems
References
Chapter 2 - Silk
2.1 Introduction
2.2 Silk
2.2.1 Silkworm Silk: Mulberry and Non-mulberry
2.2.2 Spider Silk
2.2.3 Other Silk
2.3 Silk Proteins
2.3.1 Silk Fibroin and Spidroin
2.3.2 Silk Sericin
2.4 From Raw Silk to Fibroin or Sericin: the Degumming Process
2.5 Application of Silk Proteins as Biomaterials
2.5.1 Silk Fibroin and Spidroin as a Biomaterial
2.5.2 Silk Sericin as a Biomaterial
References
Chapter 3 - Silk-fibroin Micro-drug Delivery Systems
3.1 Introduction
3.2 Silk Fibroin Microparticles and Microspheres
3.3 Silk Fibroin Microcapsules
3.4 Silk Fibroin Microneedles
3.5 Silk Fibroin Microfibers
References
Chapter 4 - Silk-fibroin Nano-drug Delivery Systems
4.1 Introduction
4.2 Silk Fibroin Nanoparticles
4.2.1 Functionalised Silk Fibroin Nanoparticles
4.3 Silk Fibroin Nanocapsules
4.4 Silk Fibroin Nanofibers
References
Chapter 5 - Silk-sericin Micro-drug Delivery Systems
5.1 Introduction
5.2 Silk Sericin Microparticles and Microspheres
5.3 Silk Sericin Microcapsules
References
Chapter 6 - Silk-sericin Nano-drug Delivery Systems
6.1 Introduction
6.2 Silk Sericin Nanoparticles
6.3 Silk Sericin Nanofibers
References
Chapter 7 - Physico-chemical Characterisation of Silk-based Materials
7.1 Introduction
7.2 Thermal Analysis
7.3 Infrared Spectroscopy
7.4 Nuclear Magnetic Resonance Spectroscopy
7.5 X-ray Diffraction
7.6 Scanning Electron Microscopy
References
Chapter 8 - From Bench to Bedside: The Long Way Towards GMP Scale-up, Preclinical and Clinical Trials for Silk-based Drug Delivery Systems
8.1 Introduction
8.2 Silk-based Drug Delivery Systems in Preclinical Animal Models
8.3 Clinical Translation of Micro and Nano-drug Delivery Systems: The Specificity of Silk-based Ones
8.3.1 Technological Challenges: Scalable and GMP Preparation Procedures
8.3.2 Biological Challenges
References
Chapter 9 - From Textile to Pharmaceutical and Cosmetic Industry: Circular Economy Applied to Silk Manufacturing Wastes
9.1 Sustainability Matters
9.2 Pollution in Textiles
9.3 Circular Economy Is One Answer
9.4 The Silk Production Processes
9.4.1 Twisting
9.4.2 Yarn Dyeing
9.4.3 Fabric Weaving
9.4.4 Fabric Dyeing or Printing
9.4.5 Finishing
9.5 From Waste to Value
9.5.1 Upgrading Fibroin Waste
9.5.2 Sericin Recovery
9.6 Sustainability- and Circularity-related Benefits
9.7 Conclusions
References
Subject Index
