Squamous epithelia form the essential lining surface of tissues in contact with the environment, including the skin, and mucosa of the oral cavity, pharynx, larynx, esophagus, respiratory and genital tracts, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV light, tobacco smoke, and infectious agents. Consequently, squamous cell carcinomas that form in these tissues are among the most common human solid tumors, and have high morbidity and mortality. The signaling pathways that regulate epithelial homeostasis and the alterations in these pathways that arise during cancer development share certain features among these different tissue sites. This book brings together timely reviews from experts in the field on mechanisms and signaling pathways such as EGFR, TGF1, NFB, PPARs and mTOR/AKT that regulate development of squamous cancer in both human and experimental mouse models, with a focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy. This comprehensive monograph will be important for researchers wishing to enter the field, for medical students, and for established basic and clinical investigators who would gain from an overview of the field.
Author(s): Barry L. Ziober, Joseph O. Humtsoe (auth.), Adam B. Glick, Carter Van Waes (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2011
Language: English
Pages: 462
Tags: Cancer Research; Pharmacology/Toxicology
Front Matter....Pages i-xx
Cell Adhesion Molecules in Carcinoma Invasion and Metastasis....Pages 1-19
Roles of Integrins in the Development and Progression of Squamous Cell Carcinomas....Pages 21-52
Alterations of Transforming Growth Factor-β Signaling in Squamous Cell Carcinomas....Pages 53-89
Aberrant Activation of HGF/c-MET Signaling and Targeted Therapy in Squamous Cancer....Pages 91-111
The Epidermal Growth Factor Receptor in Normal and Neoplastic Epithelia....Pages 113-129
Cyclooxygenase-2 Signaling in Squamous Cell Carcinomas....Pages 131-147
Interacting Signaling Pathways in Mouse Skin Tumor Initiation and Progression....Pages 149-164
Protein Kinase C and the Development of Squamous Cell Carcinoma....Pages 165-184
The Transcription Factor AP-1 in Squamous Cell Carcinogenesis: Lessons from Mouse Models of Skin Carcinogenesis....Pages 185-199
NF-κB, IκB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas....Pages 201-222
Regulation of Squamous Cell Carcinoma Carcinogenesis by Peroxisome Proliferator-Activated Receptors....Pages 223-240
p63 in Squamous Differentiation and Cancer....Pages 241-259
Effects of Natural and Synthetic Retinoids on the Differentiation and Growth of Squamous Cancers....Pages 261-282
Regulation of Keratinocyte Differentiation by Vitamin D and Its Relationship to Squamous Cell Carcinoma....Pages 283-303
Epidermal Growth Factor Receptor-Targeted Therapies....Pages 305-333
Targeting UVB Mediated Signal Transduction Pathways for the Chemoprevention of Squamous Cell Carcinoma....Pages 335-363
Molecular-Targeted Chemotherapy for Head and Neck Squamous Cell Carcinoma....Pages 365-382
Effects and Therapeutic Potential of Targeting Dysregulated Signaling Axes in Squamous Cell Carcinoma: Another Kinase of Transcription and Mammalian Target of Rapamycin....Pages 383-405
Head and Neck Cancer and the PI3K/Akt/mTOR Signaling Network: Novel Molecular Targeted Therapies....Pages 407-429
High Throughput Molecular Profiling Approaches for the Identifications of Genomic Alterations and Therapeutic Targets in Oral Cancer....Pages 431-452
Back Matter....Pages 453-462
