Signal Transduction: Principles, Pathways, and Processes

Signal Transduction Chapters online at cshperspectives.org and perspectivesinmedicine.org All rights reserved # 2014 by Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York Printed in the United States of America Publisher John Inglis Director of Editorial Development Jan Argentine Project Manager Inez Sialiano Permissions Coordinator Carol Brown Production Editor Diane Schubach Production Manager/Cover Designer Denise Weiss Front cover artwork: Drawing by Nigel Hynes. Library of Congress Cataloging-in-Publication Data Signal transduction / edited by Lewis C. Cantley, Harvard Medical School, Tony Hunter, Salk Institute for Biological Studies, Richard Sever, Cold Spring Harbor Laboratory, Jeremy Thorner, University of California at Berkeley. p. cm. Summary: “This textbook provides a comprehensive view of signal transduction, covering both the fun- damental mechanisms involved and their roles in key biological processes. It first lays out the basic prin- ciples of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that oper- ate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function”– Provided by publisher. Includes bibliographical references and index. ISBN 978-0-87969-901-7 (hardback) 1. Cellular signal transduction. 2. Developmental biology. 3. Pathology, Molecular. I. Cantley, Lewis, editor of compilation. II. Hunter, Tony, 1943- editor of compilation. III. Sever, Richard, editor of compi- lation. IV. Thorner, Jeremy W., editor of compilation. QP517.C45S534 2013 571.7′ 4--dc23 2013043753 10 9 8 7 6 5 4 3 2 1 All World Wide Web addresses are accurate to the best of our knowledge at the time of printing. Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Cold Spring Harbor Laboratory Press, provided that the appropriate fee is paid di- rectly to the Copyright Clearance Center (CCC). Write or call CCC at 222 Rosewood Drive, Danvers, MA 01923 (978-750-8400) for information about fees and regulations. Prior to photocopying items for edu- cational classroom use, contact CCC at the above address. Additional information on CCC can be ob- tained at CCC Online at www.copyright.com. For a complete catalog of all Cold Spring Harbor Laboratory Press publications, visit our website at www.cshlpress.org.