The objectives in this special issue are (1) to critically review current information on the mechanisms coupling extracellular regulatory signals to regulation of cross-bridge cycling and proliferation in smooth muscle, and (2) identify significant gaps or unresolved issues that are important topics for future research. The experimental and analytical difficulties discussed above are increasingly recognized and surmounted. Elucidation of the molecular and cellular events underlying the biologal properties of smooth muscle is in the midst of a period of rapid progress. While the reviews reveal many gaps to be filled and illustrate areas of contention, they also capture the excitement of new discoveries.
Author(s): Richard A. Murphy (auth.)
Series: Reviews of Physiology, Biochemistry and Pharmacology 134
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 1999
Language: English
Pages: 321
Tags: Human Physiology
Signal transduction and regulation in smooth muscle: Problems and progress....Pages 1-6
Applicability of the sliding filament/crossbridge paradigm to smooth muscle....Pages 7-61
Regulation of cross-bridge cycling by Ca 2+ in smooth muscle....Pages 63-146
Calcium permeant ion channels in smooth muscle....Pages 147-199
Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases....Pages 201-234
Molecular and cellular phenotypes and their regulation in smooth muscle....Pages 235-320
