The book blends basic and clinical research on respiratory carcinogensis. The contributions tackle a variety of respiratory-related cancers, notably non-small cell lung carcinoma, pleural mesothelioma, mediastinal tumors, or larynx cancer. The focus is on the search for novel molecular markers, derived from easily accessible tissues in clinical settings, such as the serum or bronchoalveolar lavage fluid, which could help diagnose cancer at an early stage and have a prognostic therapeutic value. The transcriptional mechanisms which endow cells with the capacity for unlimited proliferation are considered, with silencing of tumor suppressor genes is the exemplar. Chapters provide insight into a variety of cancer-related disorders of the respiratory tract, novel ways of differential diagnosis and treatment. The aim is to bring the current clinical procedures into alignment with the latest basic research findings. The book is a text for respiratory researchers, clinicians, and pathologists.
Author(s): Mieczyslaw Pokorski (eds.)
Series: Advances in Experimental Medicine and Biology 852
Edition: 1
Publisher: Springer International Publishing
Year: 2015
Language: English
Pages: 73
Tags: Cancer Research; Pneumology/Respiratory System; Cytokines and Growth Factors
Front Matter....Pages i-x
The Role of Mediastinoscopy in the Diagnosis of Thoracic Disease: One-Year Single Center Experience....Pages 1-4
Shoulder Ring Complaints as a Rare First Symptom of Malignant Pleural Mesothelioma....Pages 5-10
Primary Prosthetic Voice Rehabilitation in Patients After Laryngectomy: Applications and Pitfalls....Pages 11-16
A Unilateral Hemothorax as a Presenting Manifestation of Mediastinal Spindle Cell Sarcoma....Pages 17-19
Diagnostic Performance of Different Pleural Fluid Biomarkers in Tuberculous Pleurisy....Pages 21-30
Low-Dose Computer Tomography as a Screening Tool for Lung Cancer in a High Risk Population....Pages 31-37
Decreased FAM107A Expression in Patients with Non-small Cell Lung Cancer....Pages 39-48
Clinical Significance of HMGB-1 and TGF-β Level in Serum and BALF of Advanced Non-Small Cell Lung Cancer....Pages 49-58
TGF-β and SMADs mRNA Expression in Pulmonary Sarcoidosis....Pages 59-69
Back Matter....Pages 71-73
