Malaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between 1 and 3 million, most of them young children in Sub-Saharan Africa.
This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases.
* Reviews the past 100 years of malaria biochemistry research providing researchers with an overview of the investigations that have been undertaken in this field
Benefit: Allows researchers to see what progress has been made so that they can use this knowledge when trying to develop the latest drug discovery tools to attack malaria
* Chronicles both biochemical successes and failures
Benefit: Allows researchers to see what has and hasn't work which they can then apply in their own research
Author(s): Irwin W. Sherman (Eds.)
Series: Advances in Parasitology 67
Edition: 1
Publisher: Academic Press
Year: 2008
Language: English
Pages: 1-409
Content:
Series Editors
Page ii
Copyright page
Page iv
Chapter 1 Introduction Review Article
Page 1
Irwin W. Sherman
Chapter 2 An Introduction to Malaria Parasites Review Article
Pages 3-7
Irwin W. Sherman
Chapter 3 The Early Years Review Article
Pages 9-13
Irwin W. Sherman
Chapter 4 Show Me the Money Review Article
Pages 15-24
Irwin W. Sherman
Chapter 5 In Vivo and In Vitro Models Review Article
Pages 25-47
Irwin W. Sherman
Chapter 6 Malaria Pigment Review Article
Pages 49-57
Irwin W. Sherman
Chapter 7 Chloroquine and Hemozoin Review Article
Pages 59-61
Irwin W. Sherman
Chapter 8 Isoenzymes Review Article
Pages 63-71
Irwin W. Sherman
Chapter 9 The Road to the Plasmodium falciparum Genome Review Article
Pages 73-85
Irwin W. Sherman
Chapter 10 Carbohydrate Metabolism Review Article
Pages 87-93
Irwin W. Sherman
Chapter 11 Pyrimidines and the Mitochondrion Review Article
Pages 95-100
Irwin W. Sherman
Chapter 12 The Road to Atovaquone Review Article
Pages 101-104
Irwin W. Sherman
Chapter 13 The Ring Road to the Apicoplast Review Article
Pages 105-110
Irwin W. Sherman
Chapter 14 Ribosomes and Ribosomal Ribonucleic Acid Synthesis Review Article
Pages 111-115
Irwin W. Sherman
Chapter 15 De Novo Synthesis of Pyrimidines and Folates Review Article
Pages 117-138
Irwin W. Sherman
Chapter 16 Salvage of Purines Review Article
Pages 139-145
Irwin W. Sherman
Chapter 17 Polyamines Review Article
Pages 147-150
Irwin W. Sherman
Chapter 18 New Permeability Pathways and Transport Review Article
Pages 151-170
Irwin W. Sherman
Chapter 19 Hemoglobinases Review Article
Pages 171-179
Irwin W. Sherman
Chapter 20 Erythrocyte Surface Membrane Proteins Review Article
Pages 181-204
Irwin W. Sherman
Chapter 21 Trafficking Review Article
Pages 205-214
Irwin W. Sherman
Chapter 22 Erythrocyte Membrane Lipids Review Article
Pages 215-227
Irwin W. Sherman
Chapter 23 Invasion of Erythrocytes Review Article
Pages 229-252
Irwin W. Sherman
Chapter 24 Vitamins and Anti‐Oxidant Defenses Review Article
Pages 253-269
Irwin W. Sherman
Chapter 25 Shocks and Clocks Review Article
Pages 271-277
Irwin W. Sherman
Chapter 26 Transcriptomes, Proteomes and Data Mining Review Article
Pages 279-298
Irwin W. Sherman
Chapter 27 Mosquito Interactions Review Article
Pages 299-323
Irwin W. Sherman
References Review Article
Pages 325-394
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Index
Pages 395-402
Contents of Previous Volumes
Pages 403-409
