Major advances in genetics, immunology, and endocrinology have necessitated a new edition of this best-selling text. However, despite the advances, recurrent pregnancy loss presents a frustrating clinical problem. There is still disagreement about the number of pregnancy losses which warrant investigation and treatment and about which investigations should be performed.
This third edition provides an authoritative and comprehensive update on advances in the understanding and management of this troubling phenomenon, covering both basic scientific topics such as genetics and cytokines, and profiles major advances in immunology, endocrinology, and thrombotic mechanism. Clinical research is discussed, as is assessment of results when applying an evidence-based approach or a more personalised approach, which is now becoming possible due to advances in the diagnosis of cause. There are lively debates on the role of progestogens and immunotherapy, which remain controversial.
Designed for specialists working in reproductive medicine clinics and those involved with maternal-fetal care, the book is also ideal for generalists and gynecologists seeking a comprehensive view of developments in the field.
Author(s): Howard J.A. Carp
Series: Series in Maternal-Fetal Medicine
Edition: 3
Publisher: CRC Press
Year: 2020
Language: English
Pages: xii+300
Cover
Half Title
Series Page
Title Page
Copyright Page
Contents
Preface
Contributors
Part I: Basic Principles
1. The Epidemiology of Recurrent Pregnancy Loss
2. The Signaling between Embryo and Mother as a Basis for the Development of Tolerance
3. Recurrent Pregnancy Loss from Evidence-Based to Personalized Medicine
Part II: Etiology
4. The Genetics of Spontaneous Abortions
5. The Endometrial Factor in Recurrent Pregnancy Loss
6. Fetal Structural Malformations and Recurrent Pregnancy Loss
7. The Endocrinology of Recurrent Pregnancy Loss
8. The Etiology of the Antiphospholipid Syndrome
9. Defects in Coagulation Factors Leading to Recurrent Pregnancy Loss
10. The Immunobiology of Recurrent Miscarriage
11. Immune Testing in Recurrent Pregnancy Loss
12. Uterine Anomalies and Recurrent Pregnancy Loss
13. The Male Factor in Recurrent Pregnancy Loss
Part III: The Developing Pregnancy
14. Ultrasound Follow-Up in Early Pregnancy
15. Threatened Miscarriage and Recurrent Pregnancy Loss
16. The Role of Cerclage and Pessaries
17. What Genetic Screening Is Appropriate in Recurrent Pregnancy Loss?
18. Obstetric Outcomes after Recurrent Pregnancy Loss
Part IV: Management
19. Investigation Protocol for Recurrent Pregnancy Loss
20. Debate: Should Progestogens Be Used in Recurrent Pregnancy Loss? Yes
21. Debate: Should Progestogens Be Used in Recurrent Pregnancy Loss? No
22. Human Chorionic Gonadotropin Supplementation in Recurrent Pregnancy Loss
23. Antiphospholipid Syndrome: Management of the Obstetric Patient
24. Can Recurrent Pregnancy Loss Be Prevented by Antithrombotic Agents?
25. Empirical In Vitro Fertilization for Recurrent Pregnancy Loss: Is It a Valid Concept?
26. Debate: Should PGT-A Still Be Performed in Recurrent Pregnancy Loss? Yes
27. Debate: Should PGT-A Still Be Performed in Recurrent Pregnancy Loss? No
28. Third Party Reproduction in Recurrent Pregnancy Loss
Part V: Immunotherapy
29. Leucocyte Immunotherapy for Recurrent Miscarriage
30. IVIg Treatment for Recurrent Pregnancy Loss
31. The Role of Filgrastim
32. Opinion: Immunotherapy Has No Place in the Treatment of Recurrent Pregnancy Loss
Index
