The aim of this book is to bring together in one volume comprehensive reviews about recombinant poxviruses with an emphasis on the potential of these viruses as new vaccines. A wide range of issues involved in producing new genetically engineered live vaccines are considered, such as efficacy,safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Thereafter the molecular biology of poxviruses, the methods of contructing vaccinia virus recombinants, and the many ways in which they may be used are described. The use of poxvirus recombinants as live vaccines, the immune responses induced by these viruses, and the results of field trials with vaccinia-rabies virus recombinants are then considered. Subsequently, the important issues of the safety and immunogenicity
of vaccinia virus are described, and lastly, two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines.
Author(s): Matthew M. Binns; Geoffrey L. Smith
Edition: 1
Publisher: CRC Press
Year: 1992
Language: English
Pages: XIV; 343
City: Boca Raton
Title Page
Preface
The Editors
Contributors
Table of Contents
Chapter 1 - Vaccinia Virus as a Vaccine, and Poxvirus Pathogenesis
Chapter 2 - Molecular Biology of Poxviruses
Chapter 3 - The Design, Construction, and Use of Vaccinia Virus Recombinants
Chapter 4 - Poxvirus Recombinants as Live Vaccines
Chapter 5 - Development and Deliberate Release of a Vaccinia-Rabies Recombinant Virus for the Oral Vaccination of Foxes Against Rabies
Chapter 6 - Immunogenicity and Antigen Presentation
Chapter 7- Safety and Attenuation of Vaccinia Virus
Chapter 8 - Avipoxvirus Vectors
Chapter 9 - Parapoxviruses: Their Biology and Potentialas Recombinant Vaccines
Index
