Recent Developments in Mass Spectrometry in Biochemistry and Medicine: Volume 2

Front Matter....Pages i-x
The Place of Mass Spectrometry in Drug Metabolism Studies....Pages 1-8
In vitro and in Vivo Studies on the Metabolism of Dibenzo [c,f]--[1,2] Diazepine....Pages 9-25
Gas Chromatographic-Mass Spectrometric Identification of Urinary Metabolites of Propildazine in Rat....Pages 27-41
Mass Spectrometric Characterization of Sydnocarb ® and its Major Metabolites in Rat....Pages 43-52
Metabolism of an Aryloxy Beta Blocking Drug....Pages 53-68
Isolation and Identification of the Chloroform Soluble Urinary Metabolites of Suloctidil in Man....Pages 69-84
Are Stable Sulfenic Acids Possible Metabolites of Suloctidil?....Pages 85-96
The Electron Impact Fragmentation of Products Related to N-(Allyl)-3,3-Diphenylpropylamine, a Metabolite from Thiopropamine ®....Pages 97-106
Urinary Metabolites from (2-Ethyl-2,3-Dihydro-5-Benzofuranyl) Acetic Acid....Pages 107-119
The Major Metabolites of Niclosamide: Identification by Mass Spectrometry....Pages 121-126
The Metabolism of Deuterium-Labelled Analogues of Δ 1 -, Δ 6 -, and Δ 7 - Tetrahydrocannabinol and the Use of Deuterium Labelling....Pages 127-147
Kinetics of Degenerate Nucleophilic Exchange Of C(3)-Hydroxy Group in 1-Methyl-3-Hydroxy-5-Phenyl-7-Cloro-2H-1,4-Benzodiazepin-2-One....Pages 149-153
On the Analysis of Fermentation Broth during Biosynthesis of Cephalosporin Antibiotics....Pages 155-162
GC-MS Analysis by Electron Impact Ionization and Chemical Ionization of Carcinogenic 2-Acetylaminofluorene and its Metabolites....Pages 163-177
The Proximo-Distal Carcinogen of the K Region of Benzo(a)Pyrene....Pages 179-189
Quantitative Determination of Vincamine in Human Plasma by Gas Chromatography - Mass Spectrometry....Pages 191-203
Mass Fragmentographic Quantification of Phosphonoacetic Acid in the Blood of Monkeys Infected with Herpesvirus Saimiri....Pages 205-213
The Determination of Blood Cyanide and Plasma Thiocyanate by Gas Chromatography-Mass Spectrometry....Pages 215-226
Present State and Future Trends of Negative Ion Mass Spectrometry in Toxicology, Forensic and Environmental Chemistry....Pages 227-255
Mass Fragmentographic Determination of Polyamines in the Urine of Premature Babies....Pages 257-268
An Assay for Schizophrenia: Mass Spectrometry Determination of Two Cadaverine Metabolites....Pages 269-281
Analysis of the Urinary Steroids from a Pathological Pregnancy by Liquid-Gel Chromatography and Gas-Chromatography-Mass Spectrometry....Pages 283-295
Identification of Atypical Bile Acids by Gas Chromatography-Mass Spectrometry-Computer Techniques....Pages 297-306
The Effects of Triisopropylacetic Acid on the Metabolic Profile of Urinary Organic Acids....Pages 307-315
Application of Chemical Ionization MS to the Study of Regional Brain Catecholamine Metabolism in (S)-α-Methyldopa Treated Rats....Pages 317-330
Concurrent Extraction and GC-MS Assay of Endogenous TP, T, IAA, 5HT and 5HIAA in Single Rat Brain Samples....Pages 331-345
A New Method for Simplified Prostaglandin Profiling by Selected Ion Monitoring....Pages 347-354
Analysis of Urinary Steroids by Liquid-Gel Chromatography and Gas Chromatography - Mass Spectrometry. Clinical Applications....Pages 355-376
A Micromethod for the Clinical Chemistry Routine Analysis of Amino Acids in Blood and Urine by Capillary Gas Liquid Chromatography of Isobutyl Esters N(O) -Heptafluorobutyrate Derivatives....Pages 377-400
Metabolic Profile of Ventricular Cerebrospinal Fluids....Pages 401-409
Energy and Metastable Characteristics in Peptides. Electron Impact Appearance Potentials of Sequence Ions in Tripeptides....Pages 411-425
The Continuous Recording of Expired C 16 O 18 O by Respiratory Mass Spectrometry After Injection of H 2 18 O into the Vascular System....Pages 427-434
A Continuous Mass Spectrometric Analysis of Expired Physiological Gases: The Pulmonary Gas Exchange....Pages 435-450
Adaptation of Respiratory Mass Spectrometer to Continuous Recording of Abundance Ratios of Stable Oxygen Isotopes....Pages 451-462
The Development of a Flexible Mass Spectrometer Catheter....Pages 463-480
Back Matter....Pages 481-492