Researchers have tried various effective treatments that prevent the progressive neurodegeneration of neurons within the brain. Parkinson’s disease (PD), Alzheimer’s disease (AD), and Multiple sclerosis (MS) are some of the most common neurodegenerative diseases (NDDs). Recent Advances in the Treatment of Neurodegenerative Disorders provides interesting updates on treatments of these neurological disorders. Ten chapters have been contributed by experts in pharmacology and give a unique perspective to reader on special topics in this area, including the treatment of neurodegenerative treatment of neurodegenerative disease through ayurveda and phytochemicals, the therapeutic role of vitamins in Parkinson’s disease, mushrooms in NDD treatment, MS treatment, ALS treatment and the use of nanoparticles and nano formulations in NDD treatment. This is an informative reference for pharmacologists, medicinal chemists and healthcare professionals (general practitioners and neurologists) seeking updates in the treatment of some common neurodegenerative disorders.
Author(s): Sachchida Nand Rai
Publisher: Bentham Science Publishers
Year: 2021
Language: English
Pages: 231
City: Sharjah
Cover
Title
Copyright
End User License Agreement
Contents
Foreword
Preface
Acknowledgements
List of Contributors
An Introduction to Neurodegenerative Diseases and its Treatment
Payal Singh1 and Sachchida Nand Rai2,*
INTRODUCTION
AYURVEDA IN NEURODEGENERATIVE DISEASES (NDS)
VITAMINS IN NEURODEGENERATIVE DISEASES (NDS)
GUT-BRAIN AXIS AND ASSOCIATED PRO AND PRE-BIOTICS THERAPY FOR NDS
NANOPARTICLES AND NANOFORMULATION BASED THERAPY FOR DIFFERENT NDS
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Recent Advancement in the Treatment of Neurodegenerative Diseases by Ayurveda
Mridula Chaturvedi and Abhishek Kumar Chaturvedi*
INTRODUCTION
OVERVIEW OF NEURODEGENERATIVE DISEASES (NDDS)
The Preamble of Common Neurodegenerative Diseases
Alzheimer's Disease (AD)
Parkinson's Disease (PD)
Huntington’s Disease (HD)
Pathogenesis of Neurodegenerative Diseases
Pathway of Development of Neurodegenerative Diseases
Common Signs & Symptoms of Neurodegenerative Diseases
Diagnosis of Neurodegenerative Diseases
A RANGE OF TREATMENT FOR THE NEURODEGENERATIVE DISEASES
The Modern System of Medicine
Medical Management
Surgical Management
Emerging Management
Ayush or Indian System of Medicine
RECENT ADVANCEMENT IN THE AYURVEDIC MANAGEMENT OF NEURODEGENERATIVE DISEASES
Ayurvedic/herbal Medicinal Plants
Different Actions of an Extract Derived from Ayurvedic Medicinal Plants
Herbo-mineral Drugs
Panchkarma (Bio-purification Procedures)
Overview of Panchkarma Therapy
Studies Conducted in Different Panchkarma Procedures
CONCLUDING REMARKS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Role of Phytochemicals in Neurodegenerative Disorders
Shambhoo Sharan Tripathi1,*, Raushan Kumar1, Prabhash Kumar Pandey1, Abhishek Kumar Singh2 and Nidhi Gupta3,4
INTRODUCTION
PATHOGENESIS OF NEURODEGENERATION
ROLE OF PHYTOCHEMICALS IN NEURODEGENERATION
NERUROPROTECTING PHYTOCHEMICALS
Epigallocatechin-3-Gallate
Berberine
Curcumin
Resveratrol
Quercetin
Fisetin
Ginsenosides
Sulforaphane (SFN)
Genistein
Allium and Allicin
Icariin
Morin
Baicalein
CONCLUSIONS
FUTURE SUGGESTION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Therapeutic Potential of Vitamins in Parkinson’s Disease
Prabhash Kumar Pandey1,2,*, Shambhoo Sharan Tripathi1, Jayant Dewangan2, Ranjan Singh3, Farrukh Jamal4 and Srikanta Kumar Rath2
INTRODUCTION
ROLE OF OXIDATIVE STRESS IN THE PATHOGENESIS OF PD
THEATRICAL ROLE OF NEUROINFLAMMATION IN THE PATHOGENESIS OF PD
NEUROPROTECTIVE ROLES OF VITAMINS IN THE TREATMENT OF PARKINSONISM
Neuroprotective Role of Vitamin B in PD
Usability of Vitamin C in PD Treatment
Role of Vitamin E in the Treatment of Pd
Role of Vitamin D as a Neuroprotectant in the Pd Treatment
CONCLUSION AND FUTURE DIRECTIONS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Potential of Gut Microbiome in the Diagnosis and Treatment of Alzheimer’s and Parkinson’s Disease
Nilofar Khan1 and Ravishankar Patil1,*
INTRODUCTION
ALZHEIMER’S DISEASE: PATHOMECHANISM, PREVALENCE, SYMPTOMS, AND TREATMENT
Prevalence of AD
Symptoms of AD
Causes of AD
Treatment Strategies for AD
Acetylcholine Esterase (Ache)
β Secretase
ϒ Secretase
Aβ Vaccination
Amyloid Anti-Aggregation Therapies
Anti-Inflammatory Drugs
Cholesterol-Lowering Drugs
PARKINSON’S DISEASE: PATHOMECHANISM, PREVALENCE, SYMPTOMS, AND TREATMENT
Prevalence of PD
Symptoms of PD
Treatment Strategies for PD
Dopamine Replacement Therapy (DRT)
L-DOPA: Promising DRT for PD
Anti-inflammatory Agents and Protein Anti-Aggregants
ROLE OF GUT MICROBIOME IN METABOLISM AND HEALTH
Role of Prebiotics in Gut Microflora Balance
Gut Microbiome and Neurodegenerative Disease
Gut and Alzheimer’s Disease
Therapeutic Role of Probiotics in AD
Prebiotics For AD
Gut Microbiome and Parkinson’s Disease
Probiotics and Prebiotics for PD
Mediterranean Diet
Ketogenic Diet and Fasting
Polyphenols
CONCLUDING REMARKS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Therapeutic Efficacy of Mushroom in Neurodegenerative Diseases
Ankita Kushwaha1,*, Vivek K. Chaturvedi2, Sachchida Nand Rai2, Sanjay C. Masih3 and M. P. Singh2
INTRODUCTION
NEUROPROTECTIVE EFFECTS OF MUSHROOMS AGAINST NEURODEGENERATIVE DISEASE
ADVANTAGEOUS EFFECTS OF MUSHROOMS AGAINST NDS
Role of Mushrooms in Alzheimer’s Disease (AD)
Mushrooms Having Beneficial Effects Against Parkinson's Pisease (PD)
CONCLUSIONS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Advances in Experimental Animal Models Provide Insights into Different Etiology and Mechanism of Multiple Sclerosis to Design Therapeutics
Sourodip Sengupta and Jayasri Das Sarma*
INTRODUCTION
CLASSIFICATION OF MS
ETIOLOGY OF MS
CLINICAL SYMPTOMS AND DIAGNOSIS
PRESENT THERAPEUTICS AND LIMITATIONS
EXPERIMENTAL ANIMAL MODELS TO UNDERSTAND THE MECHANISMS OF MS
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE)
EXPERIMENTAL VIRAL-INDUCED MODEL OF MS
TMEV MODEL
MHV MODEL
MHV MEDIATED IMMUNE RESPONSES
Recombinant Demyelinating (DM) And Non-Demyelinating (NDM) Mhv Strains
CONCLUDING REMARKS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Novel Therapeutic Targets in Amyotrophic Lateral Sclerosis
Priyanka Gautam, Mukesh Kumar Jogi and Abhishek Pathak*
INTRODUCTION
HISTORY
EPIDEMIOLOGY
SIGN AND SYMPTOMS
CLINICAL CHARACTERISTICS
GENETICS
MUTATION
ALS PATHOGENIC PATHWAYS AS THERAPEUTIC TARGETS
TARGETING OXIDATIVE STRESS
TARGETING GLUTAMATE TRANSPORT
TARGETING PROTEIN AGGREGATION
TARGETING MITOCHONDRIAL DYSFUNCTION
TARGETING APOPTOSIS
TARGETING NEUROINFLAMMATION
TARGETING GLIAL CELLS (MICROGLIA AND ASTROCYTES)
TARGETING DYSREGULATED RNA PROCESS
TARGETING NEUROMUSCULAR JUNCTION
TARGETING GENE
CONCLUDING REMARKS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Impact of Nano-Formulations of Natural Compounds in the Management of Neuro degenerative Diseases
Hemraj Heer1, Vishav Prabhjot Kaur1, Tania Bajaj1, Arti Singh2, Priyanka Bajaj3 and Charan Singh1,*
INTRODUCTION
NEUROPROTECTIVE POTENTIAL OF NATURAL PRODUCTS
APPROACHES FOR CNS TARGETED NATURAL COMPOUNDS DELIVERY
NANO-BASED DELIVERY SYSTEMS FOR NEURODEGENERATIVE DISORDERS
LIPIDIC NANOMATERIALS
Liposomes
Solid Lipid Nanoparticles and Nanostructured Lipid Carrier Systems
Carbon Nanomaterials
Carbon Nanotubes
Nanodiamonds
Polymeric Systems
Dendrimers
Metal-organic Frameworks (MOFs)
Semiconducting Nanoparticles And Quantum Dots
Phospholipid Complexes
METHODS OF NANOFORMULATIONS PREPARATION
Emulsion-solvent Evaporation Method
Solvent Diffusion Method
Salting Out Method
Supercritical Fluid Technique
Polymerization Technique
NATURAL COMPOUNDS NANO-DELIVERY IN NEURO DEGENERATIVE DISEASES
Alzheimer’s Disease
Huntington’s Disease
Parkinson's Disease
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Recent Advancement in the Nanoparticles Mediated Therapeutics of Parkinson’s Disease
Vivek K. Chaturvedi1, Payal Singh2 and M.P. Singh1,*
INTRODUCTION
NANOPARTICLES BASED THERAPY FOR PARKINSON’S DISEASE
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Subject Index
