Oxidative stress is one of the major symptoms accompanying physiological functions and numerous diseases. Oxidants and free radicals are connected with diseases such as cancer, diabetes, infectious, cardiovascular and neurodegenerative diseases and also in the aging process itself. Therefore, comprehensive knowledge of the underlying mechanisms of oxidant and free radical production and the defence against this permanent threat to cells is important for the understanding of many physiological and pathophysiological processes. This book overviews the basic mechanisms of oxidant formation and antioxidant defences. In addition, the formation of oxidants and their detoxification, the damage of macromolecules and the major repair and removal systems will be highlighted.
Author(s): Hans Nohl, Andrey V. Kozlov, Lars Gille, Katrin Staniek (auth.), Tilman Grune (eds.)
Series: The Handbook of Environmental Chemistry, Vol. 2: Reactions and Processes, Part O
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2005
Language: English
Pages: 240
Tags: Ecotoxicology; Geoecology/Natural Processes; Occupational Medicine/Industrial Medicine; Pharmacology/Toxicology; Ecology
Endogenous Oxidant-Generating Systems....Pages 1-18
Environmental Oxidative Stress – Environmental Sources of ROS....Pages 19-31
Chemical Modifications of Biomolecules by Oxidants....Pages 33-62
The Broad Spectrum of Responses to Oxidative Stress in Proliferating Cells....Pages 63-75
Low Molecular Weight Antioxidants....Pages 77-90
Glutathione....Pages 91-108
Superoxide Dismutases and Catalase....Pages 109-149
DNA Repair: Mechanisms and Measurements....Pages 151-175
Protein Repair and Degradation....Pages 177-201
Modulation of Cellular Signaling Processes by Reactive Oxygen Species....Pages 203-218
Mitochondrial Free Radical Production, Antioxidant Defenses and Cell Signaling....Pages 219-234
