Reflux is an important factor in many different lung diseases and its manifestations are under recognised. The pathological basis of reflux has recently undergone major changes and clinicians' understanding has improved with diagnostic technology. This book aims to educate and inform professionals of these latest developments and give practical advice to their application in the clinical setting. It contains contributions written by world experts discussing their latest research, ideas and future directions in this fast moving area. Pharmacological, surgical and behavioural techniques in the prevention and treatment of reflux are discussed in each chapter. Special circumstances, such as eosinophilic inflammation in relation to asthma, cough and eosinophilic bronchitis are also highlighted. This book brings together the various different strands of research in reflux in relation to airways disease, to provide readers with a board summary of how the different but overlapping areas impacted by reflux affect the respiratory tract.
Author(s): Alyn H. Morice, Peter W. Dettmar
Publisher: Springer
Year: 2018
Language: English
Pages: 366
Front Matter ....Pages i-xix
Front Matter ....Pages 1-1
Diagnostic Confusion Through the Ages (Alyn H. Morice)....Pages 3-8
An Overview of Gastroesophageal Reflux Disease (Serhat Bor)....Pages 9-27
Chemical Composition of Refluxate (Iain A. Brownlee)....Pages 29-39
Pathological Processes (Jeffrey P. Pearson, Adil Aldhahrani, Peter I. Chater, Matthew D. Wilcox)....Pages 41-53
Pathophysiology in the Lung (Chris Ward, Rhys Jones, Mellissa Friel, Eoin Hunt, Des Murphy)....Pages 55-69
Effect of Reflux on Cough Sensitivity and Bronchial Responsiveness (Peter V. Dicpinigaitis)....Pages 71-78
Front Matter ....Pages 79-79
Questionnaire Diagnosis of Airways Reflux (Shoaib Faruqi)....Pages 81-90
Pepsin Detection as a Diagnostic Test for Reflux Disease (Peter W. Dettmar, Rhianna K. Lenham, Adrian J. Parkinson, Andrew D. Woodcock)....Pages 91-104
Imaging Reflux (Luca Marciani)....Pages 105-114
High Resolution Oesophageal Manometry in the Investigation of Unexplained Cough (Jennifer Burke, Warren Jackson)....Pages 115-124
Cough Monitoring in Reflux Lung Disease (Aakash K. Pandya, Joanne E. Kavanagh, Surinder S. Birring)....Pages 125-133
Front Matter ....Pages 135-135
The Relationship Between Asthma and Gastro-Esophageal Reflux (Adalberto Pacheco)....Pages 137-164
Gastroesophageal Reflux Disease (GERD) and COPD (Nabid Zaer, John R. Hurst)....Pages 165-174
Gastro Oesophageal Reflux and Bronchiectasis (Kirsty L. Hett, Ben Hope-Gill)....Pages 175-186
Reflux Aspiration and Cystic Fibrosis (Ans Pauwels)....Pages 187-194
Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis (Lawrence A. Ho, Ganesh Raghu)....Pages 195-204
Gastro-Oesophageal Reflux Disease (GORD) and Chronic Cough (Lorcan McGarvey, Kian Fan Chung)....Pages 205-212
Reflux and Aspiration: Their Presumed Role in Chronic Cough and the Development of End-Stage Lung Disease (Jacob A. Klapper, Brian Gulack, Matthew G. Hartwig)....Pages 213-223
Front Matter ....Pages 225-225
Reflux and Aspiration in the Intensive Care Unit (Peter V. Dicpinigaitis)....Pages 227-233
Incidence and Risk of Aspiration in Mechanically Ventilated Patients (Miles J. Klimara, Rahul Nanchal, Nikki Johnston)....Pages 235-244
Reflux in Pediatrics (Nina Gluchowski, Rachel Rosen)....Pages 245-259
Aspiration in the Elderly (Midori Miyagi, Satoru Ebihara)....Pages 261-265
Front Matter ....Pages 267-267
Acid Suppression for Management of Gastroesophageal Reflux Disease: Benefits and Risks (Carmelo Scarpignato, Luigi Gatta)....Pages 269-291
Reflux Inhibitors and Prokinetics (Woo-Jung Song)....Pages 293-302
Macrolides, Reflux and Respiratory Disease (Michael G. Crooks, Tamsin Nash)....Pages 303-331
Inhaled, Nebulised and Oral Bronchodilators in Reflux Disease (K. Suresh Babu, Jaymin B. Morjaria)....Pages 333-341
Speech Pathology: Reflux Aspiration and Lung Diseases (Anne E. Vertigan)....Pages 343-355
Anti Reflux Surgery (Zainab Rai, Alyn H. Morice, Peter Sedman)....Pages 357-363
Back Matter ....Pages 365-370
