This thesis reports on the development of the first quantum enhanced microscope and on its applications in biological microscopy. The first quantum particle-tracking microscope, described in detail here, represents a pioneering advance in quantum microscopy, which is shown to be a powerful and relevant technique for future applications in science and medicine.
The microscope is used to perform the first quantum-enhanced biological measurements -- a central and long-standing goal in the field of quantum measurement. Sub diffraction-limited quantum imaging is achieved, also for the first time, with a scanning probe imaging configuration allowing 10-nanometer resolution.
Author(s): Michael Taylor (auth.)
Series: Springer Theses
Edition: 1
Publisher: Springer International Publishing
Year: 2015
Language: English
Pages: 195
Tags: Spectroscopy and Microscopy; Quantum Optics; Biophysics and Biological Physics
Front Matter....Pages i-xix
Introduction....Pages 1-37
Front Matter....Pages 39-39
The Total Information Carried by the Light....Pages 41-50
The Quantum Noise Limit for a Specific Measurement....Pages 51-58
Characterizing Quadrant Detection....Pages 59-68
Front Matter....Pages 69-70
Interferometer Enhanced Particle Tracking....Pages 71-86
Homodyne Based Particle Tracking....Pages 87-93
Lock-In Particle Tracking....Pages 95-104
Selective Measurement by Optimized Dark-Field Illumination Angle....Pages 105-113
Technical Constraints on Sensitivity....Pages 115-121
Front Matter....Pages 123-123
Surpassing the Quantum Limit....Pages 125-141
Biological Measurement Beyond the Quantum Limit....Pages 143-151
Subdiffraction-Limited Quantum Imaging of a Living Cell....Pages 153-168
Further Extensions....Pages 169-178
Summary and Conclusion....Pages 179-182
Back Matter....Pages 183-195
