Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.
Author(s): Niki Chondrogianni, Elah Pick, Anna Gioran
Series: Oxidative Stress and Disease
Publisher: CRC Press
Year: 2021
Language: English
Pages: 276
City: Boca Raton
Cover
Half Title
Series Page
Title Page
Copyright Page
Contents
Preface
Contributors
The Editors
1. RIBOSOMAL PAUSES DURING TRANSLATION AND PROTEOSTASIS
2. PROTEIN FOLDING AND MISFOLDING: DECIPHERING MECHANISMS OF AGE RELATED DISEASES
3. TRANSCRIPTIONAL REGULATION OF PROTEOSTATIC MECHANISMS
4. MicroRNAs AS CENTRAL REGULATORS OF ADULT MYOGENESIS AND PROTEOSTASIS LOSS IN SKELETAL MUSCLE AGING
5. mRNA GRANULES AND PROTEOSTASIS IN AGING AND AGE-RELATED DISEASES
6. PHOSPHOLIPIDS AND THE UNFOLDED PROTEIN RESPONSE
7. UBIQUITIN LIGASES INVOLVED IN PROGEROID SYNDROMES AND AGE ASSOCIATED PATHOLOGIES
8. ROLE OF SUMOylation IN NEURODEGENERATIVE DISEASES AND INFLAMMATION
9. NEDD8 AND OXIDATIVE STRESS
10. STRUCTURE, FUNCTION AND REGULATORS OF THE 20S PROTEASOME
11. CELLULAR RESPONSES TO PROTEASOME IMPAIRMENT
12. PROTEASOME FATE IN AGING AND PROTEINOPATHIES
13. THE PROTEASOMAL SYSTEM IN
CANCER
14. PROTEOSTASIS AND SKIN AGING
15. REACTIVE OXYGEN SPECIES AND PROTEIN HOMEOSTASIS IN SKELETAL MUSCLE REGENERATION
16. PROTEIN DEGRADATION IN CARDIAC HEALTH AND DISEASE
17. AUTOPHAGY IN AGING AND OXIDATIVE STRESS
18. AUTOPHAGY IN AGING AND LONGEVITY EXEMPLIFIED BY THE AGING HEART
Index