Protein Physics is a lively presentation of the most general problems of protein structure, folding and function from the physics and chemistry perspective, based on lectures given by the authors. It deals with fibrous, membrane and, most of all, with the best studied water-soluble globular proteins, in both their native and denatured states. The major aspects of protein physics are covered systematically, physico-chemical properties of polypeptide chains; their secondary structures; tertiary structures of proteins and their classification; conformational transitions in protein molecules and their folding; intermediates of protein folding; folding nuclei; physical backgrounds of coding the protein structures by their amino acid sequences and protein functions in relation to the protein structure. The book will be of interest to undergraduate and graduate level students and researchers of biophysics, biochemistry, biology and material science. * Designed for a wide audience of undergraduate and graduate students, as well as being a reference for researchers in academia and industry * Covers the most general problems of protein structure, folding, and function and introduces the key concepts and theories * Deals with fibrous, membrane and especially water-soluble globular proteins, in both their native and denatured states * Summarizes and presents in a systematic form the results of several decades of world wide fundamental research on protein physics, structure and folding * Examines experimental data on protein structure in the post-genome era
Author(s): Alexei V. Finkelstein, Oleg Ptitsyn
Year: 2005
Language: English
Pages: 375
Front Cover......Page 1
Protein Physics: A Course of Lectures......Page 4
Copyright Page......Page 5
CONTENTS......Page 6
Preface......Page 14
Foreword......Page 18
Acknowledgments......Page 20
Part I: INTRODUCTION......Page 22
Lecture 1......Page 24
Part II: ELEMENTARY INTERACTIONS IN AND AROUND PROTEINS......Page 34
Lecture 2......Page 36
Lecture 3......Page 44
Lecture 4......Page 54
Lecture 5......Page 64
Lecture 6......Page 78
Part III: SECONDARY STRUCTURES OF POLYPEPTIDE CHAINS......Page 94
Lecture 7......Page 96
Lecture 8......Page 106
Lecture 9......Page 124
Lecture 10......Page 138
Part IV: PROTEIN STRUCTURES......Page 146
Lecture 11......Page 148
Lecture 12......Page 156
Lecture 13......Page 166
Lecture 14......Page 182
Lecture 15......Page 196
Lecture 16......Page 210
Part V: COOPERATIVE TRANSITIONS IN PROTEIN MOLECULES......Page 226
Lecture 17......Page 228
Lecture 18......Page 248
Lecture 19......Page 260
Lecture 20......Page 272
Lecture 21......Page 284
Part VI: PREDICTION AND DESIGN OF PROTEIN STRUCTURE......Page 300
Lecture 22......Page 302
Lecture 23......Page 318
Part VII: PHYSICAL BACKGROUND OF PROTEIN FUNCTIONS......Page 332
Lecture 24......Page 334
Lecture 25......Page 352
Afterword......Page 366
Recommended reading......Page 368
Index......Page 370