ITAe, 2012. – 476 p. – ISBN: 9789535107378.This book covers most important research hot points on protein phosphorylation and human health, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases.
Contents
Akt, mTOR and AMPK in Cancer and Metabolic Disorders
Protein Phosphorylation as a Key Mechanism of mTORC1/2 Signaling Pathways
Sestrins Link Tumor Suppressors with the AMPK-TOR Signaling Network
Regulation of Autophagy by Protein Phosphorylation
Fatty Acids Stimulate Glucose Uptake by the PI3K/AMPK/Akt and PI3K/ERK1/2 Pathways
Protein Phosphorylation in Transcription, pre-mRNA Splicing and DNA Damage
RNA Polymerase II Phosphorylation and Gene Expression Regulation
The Prp4 Kinase: Its Substrates. Function and Regulation in Pre-mRNA Splicing
More Than Just an OFF-Switch: The Essential Role of Protein Dephosphorylation in the Modulation of BDNF Signaling Events
Signalling DNA Damage
Tyrosine Protein Kinases in Receptor Signaling and Diseases
Tyrosine Phosphorylation of the NMDA Receptor Following Cerebral Ischaemia
Function of Flotillins in Receptor Tyrosine Kinase Signaling and Endocvtosis: Role of Tyrosine Phosphorylation and Oligomerization
Role of Tyrosine Kinase A Receptor (TrkA) on Pathogenicity of Clostridium perfringens Alpha-Toxin
Modulation of HER2 Tyrosine/Threonine Phosphorylation and Cell Signalling
Protein Kinases and Phosphatases in Cell Cycle Regulation
Protein Phosphorylation is an Important Tool to Change the Fate of Key Players in the Control of Cell Cycle Progression in Saccharomyces
Phosphorylation Mediated Regulation of Cdc25 Activity, Localization and Stability
Histidine Kinases in Two-Component Systems
Bacterial Two-Component Systems: Structures and Signaling Mechanism
