Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.
Author(s): Steven G. Clarke and Fuyuhiko Tamanoi (Eds.)
Series: The Enzymes 24
Edition: 1
Publisher: Elsevier, Academic Press
Year: 2006
Language: English
Pages: 3-570
Content:
Preface
Pages xi-xii
Fuyuhiko Tamanoi, Steven G. Clarke
1 Protein methyltransferases: Their distribution among the five structural classes of adomet-dependent methyltransferases Original Research Article
Pages 3-22
Heidi L. Schubert, Robert M. Blumenthal, Xiaodong Cheng
2 The family of protein arginine metkyltransferases Original Research Article
Pages 31-50
Mark T. Bedford
3 Diverse roles of protein arginine methyltransferases Original Research Article
Pages 51-103
Anne E. McBride
4 Structure of protein arginine methyltransferases Original Research Article
Pages 105-121
Xing Zhang, Xiaodong Cheng
5 Methylation and demethylation of his tone arg and lys residues in chromatin structure and function Original Research Article
Pages 123-153
Yanming Wang
6 Structure of SET domain protein lysine methyltransferases Original Research Article
Pages 155-178
Bing Xiao, Steven J. Gamblin, Jonathan R. Wilson
7 Non-histone protein lysine methyltransferases: Structure and catalytic roles Original Research Article
Pages 179-228
Lynnette M.A. Dirk, Raymond C. Trievel, Robert L. Houtz
8 Demethylation pathways for histone methyllysine residues Original Research Article
Pages 229-242
Federico Forneris, Claudia Binda, MariaAntonietta Vanoni, Andrea Mattevi, Elena Battagliol
9 Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt): A key enzyme in CaaX processing Original Research Article
Pages 245-272
Jessica L. Anderson, Christine A. Hrycyna
10 Genetic approaches to understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins Original Research Article
Pages 273-301
Stephen G. Young, Steven G. Clarke, Martin O. Bergoc, Mark Phillips, Loren G. Fong
11 Reversible methylation of protein phosphatase 2A Original Research Article
Pages 303-324
Sari Longin, Jozef Goris
12 Reversible methylation of glutamate residues in the receptor proteins of bacterial sensory systems Original Research Article
Pages 325-382
Frances M. Antommattei, Robert M. Weis
13 Protein L-isoaspartyl, D-aspartyl O-methyltransferases: Catalysts for protein repair Original Research Article
Pages 385-433
Clare M. O'Connor
14 Modification of glutamine residues in proteins involved in translation Original Research Article
Pages 437-453
Heidi L. Schubert
15 Modification of phycobiliproteins at asparagine residues Original Research Article
Pages 455-463
Alan V. Klotz
16 Inhibition of mammalian protein methyltransferases by 5′-methylthioadenosine (MTA): A mechanism of action of dietary same? Original Research Article
Pages 467-493
Steven G. Clarke
Author index
Pages 495-553
Index
Pages 555-570,I-XVI
