Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research.
Author(s): Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka (eds.)
Series: Advances in Biochemistry in Health and Disease 12
Edition: 1
Publisher: Springer International Publishing
Year: 2015
Language: English
Pages: 378
Tags: Cancer Research; Protein Science; Apoptosis
Front Matter....Pages i-xxiii
Front Matter....Pages 1-1
Yeast Asf1 Protein as Modulator of Protein Kinase CK2 Activity....Pages 3-16
Impressions from the Conformational and Configurational Space Captured by Protein Kinase CK2....Pages 17-33
Structural Basis of CK2 Regulation by Autoinhibitory Oligomerization....Pages 35-47
Maize RNA-Binding Protein ZmTGH: A New Partner for CK2β1 Regulatory Subunit....Pages 49-55
Front Matter....Pages 57-57
CK2 in Organ Development, Physiology, and Homeostasis....Pages 59-79
Protein Kinase CK2: A Window into the Posttranslational Regulation of the E(spl)/HES Repressors from Invertebrates and Vertebrates....Pages 81-107
Tissue-Specific Functions and Regulation of Protein Kinase CK2....Pages 109-123
CK2 Function in the Regulation of Akt Pathway....Pages 125-140
Cellular Zinc Signalling Is Triggered by CK2....Pages 141-157
CK2: A Global Regulator of Cell Death....Pages 159-181
Protein Kinase CK2: Systematic Relationships with Other Posttranslational Modifications....Pages 183-196
Role for Protein Kinase CK2 on Cell Proliferation: Assessing CK2 Complex Components in the Nucleus During the Cell Cycle Progression....Pages 197-226
“Genuine” Casein Kinase: The False Sister of CK2 That Phosphorylates Secreted Proteins at S-x-E/pS Motifs....Pages 227-237
Front Matter....Pages 239-239
Dysregulated Expression of Protein Kinase CK2 in Renal Cancer....Pages 241-257
Protein Kinase CK2 and Dysregulated Oncogenic Inflammatory Signaling Pathways....Pages 259-280
CIGB-300: A Promising Anti-Casein Kinase 2 (CK2) Peptide for Cancer Targeted Therapy....Pages 281-298
Targeting CK2 for Cancer Therapy Using a Nanomedicine Approach....Pages 299-315
Front Matter....Pages 317-317
Screening of DTP Compound Libraries for CK2 Inhibitors with Focus on Natural Products....Pages 319-340
CK2 Inhibitors and the DYRK Family Protein Kinases....Pages 341-359
Sensitivity of Protein Kinase CK2 to ATP/GTP and Specific Inhibitors Depends on Complexity of Interacting Proteins....Pages 361-374
Back Matter....Pages 375-378
