Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor-promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents.
Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. It is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable.
Protein Kinase C in Cancer Signaling and Therapy is composed of twenty-three chapters written by leading experts in the field. The book is divided into four sections: Regulation of PKC isozyme function: from genes to biochemistry, PKC isozymes in the control of cell function, PKC isozymes in cancer, and PKC isozymes as targets for cancer therapy. Each section of Protein Kinase C in Cancer Signaling and Therapy begins with an introduction by an established professional in the field of Protein kinase C, followed by chapters that elucidate the importance of PKC in current cancer research.
Author(s): Alex Toker (auth.), Marcelo G. Kazanietz (eds.)
Series: Current Cancer Research
Edition: 1
Publisher: Humana Press
Year: 2010
Language: English
Pages: 494
Tags: Cancer Research; Pharmacology/Toxicology
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective....Pages 3-8
Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids....Pages 9-23
Phorbol Esters and Diacylglycerol: The PKC Activators....Pages 25-53
Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals....Pages 55-78
Regulation of PKC by Protein–Protein Interactions in Cancer....Pages 79-103
Front Matter....Pages 106-106
Introduction: PKC Isozymes in the Control of Cell Function....Pages 107-115
Regulation and Function of Protein Kinase D Signaling....Pages 117-154
PKC and Control of the Cell Cycle....Pages 155-188
PKC and the Control of Apoptosis....Pages 189-222
Atypical PKCs, NF-κB, and Inflammation....Pages 223-244
Front Matter....Pages 246-246
Introduction: PKC and Cancer....Pages 247-251
Protein Kinase C, p53, and DNA Damage....Pages 253-265
PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways....Pages 267-286
PKC–PKD Interplay in Cancer....Pages 287-303
Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer....Pages 305-321
PKC Isozymes and Skin Cancer....Pages 323-345
PKC and Breast Cancer....Pages 347-360
PKC and Prostate Cancer....Pages 361-378
Protein Kinase C and Lung Cancer....Pages 379-399
Front Matter....Pages 402-402
Introduction....Pages 403-407
Front Matter....Pages 402-402
PKC and Resistance to Chemotherapeutic Agents....Pages 409-429
PKCδ as a Target for Chemotherapeutic Drugs....Pages 431-453
Atypical PKCs as Targets for Cancer Therapy....Pages 455-484
Back Matter....Pages 485-494
