This handy pocket book provides a summary of research on the role of dopamine in the cause and clinical presentation of schizophrenia. It includes an overview of the history and etiology of schizophrenia, as well as a review of schizophrenia and modern management. It highlights the genetics of schizophrenia, including the function of dopamine and 5HT receptors, COMT, and drug metabolism. It includes key information on the role of the neurotransmitters dopamine, glutamate, and serotonin, as well as details of the role of dopamine in the etiology of schizophrenia. The book also explains the mechanism of action of anti-psychotic drugs, including the anti-psychotic effects of dopamine receptor modulation.
Author(s): Arvid Carlsson, Yves Lecrubier
Edition: 1
Year: 2004
Language: English
Pages: 136
Book Cover......Page 1
Title......Page 2
Copyright......Page 3
Contents......Page 4
Contributors......Page 5
Preface......Page 8
Acknowledgements......Page 9
1 Introduction......Page 11
2 Genetics of schizophrenia......Page 14
3 Neurotransmitters in schizophrenia......Page 23
4 The role of dopamine in the etiology and pathophysiology of schizophrenia......Page 37
5 The role of dopamine in the phenomenology of schizophrenia......Page 46
6 The role of D2 receptors in the action of antipsychotic drugs......Page 57
7 Amisulpride: a selective dopaminergic agent and atypical antipsychotic......Page 67
8 Conclusions and perspectives......Page 84
Bibliography......Page 89
Index......Page 97
