Prion Proteins

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Genetics of Prion Disease, by S. Lloyd, S. Mead and J. Collinge.- Atypical Prion Diseases in Humans and Animals, by M. A. Tranulis, S. L. Benestad, T. Baron and H. Kretzschmar.- Chronic Wasting Disease, by S. Gilch, N. Chitoor, Y. Taguchi, M. Stuart, J. E. Jewell and H. M. Schätzl.- Transgenic Mouse Models and Prion Strains, by G. C. Telling.- Neuroprotective and Neurotoxic Signaling by the Prion Protein, by U. K. Resenberger, K. F. Winklhofer and J. Tatzelt.- Prion Seeded Conversion and Amplification Assays, by C. D. Orrú and B. Caughey.- Prion Protein and Its Conformational Conversion: A Structural Perspective, by W. K. Surewicz and M. I. Apostol.- Molecular Dynamics as an Approach to Study Prion Protein Misfolding and the Effect of Pathogenic Mutations, by M.W. van der Kamp and V. Daggett.- Chemical Biology of Prion Protein: Tools to Bridge the In Vitro/Vivo Interface, by R. Seidel and M. Engelhard.- The PrP-Like Proteins Shadoo and Doppel, by D. Westaway, N. Daude, S. Wohlgemuth and P. Harrison.- Fungal Prions: Structure, Function and Propagation, by M. F. Tuite, R. Marchante and V. Kushnirov.

Author(s): Sarah Lloyd, Simon Mead, John Collinge (auth.), Jörg Tatzelt (eds.)
Series: Topics in Current Chemistry 305
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2011

Language: English
Pages: 304
City: Berlin
Tags: Organic Chemistry; Bioorganic Chemistry; Protein Science; Medicinal Chemistry

Front Matter....Pages i-xii
Genetics of Prion Disease....Pages 1-22
Atypical Prion Diseases in Humans and Animals....Pages 23-50
Chronic Wasting Disease....Pages 51-77
Transgenic Mouse Models and Prion Strains....Pages 79-99
Neuroprotective and Neurotoxic Signaling by the Prion Protein....Pages 101-119
Prion Seeded Conversion and Amplification Assays....Pages 121-133
Prion Protein and Its Conformational Conversion: A Structural Perspective....Pages 135-167
Molecular Dynamics as an Approach to Study Prion Protein Misfolding and the Effect of Pathogenic Mutations....Pages 169-197
Chemical Biology of Prion Protein: Tools to Bridge the In Vitro / Vivo Interface....Pages 199-223
The PrP-Like Proteins Shadoo and Doppel....Pages 225-256
Fungal Prions: Structure, Function and Propagation....Pages 257-298
Back Matter....Pages 299-302