Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed.
In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.
Author(s): Leif W. Ellisen, Daniel A. Haber (auth.), Daniel C. Chung, Daniel A. Haber (eds.)
Edition: 1
Publisher: Springer US
Year: 2010
Language: English
Pages: 227
Tags: Oncology; Human Genetics
Front Matter....Pages i-xi
Basic Principles of Cancer Genetics....Pages 1-22
Principles of Cancer Genetic Counseling and Genetic Testing....Pages 23-40
Genetics of Hereditary Breast Cancer....Pages 41-51
Surgical Management of Hereditary Breast and Ovarian Cancer....Pages 53-62
Hereditary Colon Cancer: Colonic Polyposis Syndromes....Pages 63-76
Hereditary Colon Cancer: Lynch Syndrome....Pages 77-88
Hereditary Pancreatic Cancer....Pages 89-96
Hereditary Diffuse Gastric Cancer....Pages 97-107
Familial Renal Cell Cancers and Pheochromocytomas....Pages 109-128
Familial Atypical Mole Melanoma (FAMM) Syndrome....Pages 129-144
Multiple Endocrine Neoplasia....Pages 145-162
Pediatric Malignancies: Retinoblastoma and Wilms’ Tumor....Pages 163-180
Neurofibromatosis and Schwannomatosis....Pages 181-193
The HapMap Project and Low-Penetrance Cancer Susceptibility Alleles....Pages 195-204
Somatic Genetic Alterations and Implications for Targeted Therapies in Cancer (GIST, CML, Lung Cancer)....Pages 205-220
Back Matter....Pages 221-227
