N-methyl-D-aspartate receptors (NMDARs) are indispensable for brain development and function. Both NMDAR hypo and hyperfunction contribute to the pathophysiology of a variety of neurological and psychiatric diseases. The papers collected in this special issue summarize the current knowledge regarding the post-transcriptional regulation of NMDA receptor expression. The expression of NMDA receptors in the fetus and newborn is reviewed as well as its response in the central nervous system to noxious stimuli during early development. Evidence and mechanisms for controlling functional expression of NMDA receptor trafficking are summarized and discussed. Neurobiologists will find a collection of essential and up-to-date information on mechanisms regulating the expression of NMDA receptors which are central to physiological and pathophysiological brain function.
Author(s): Nikolaus J. Sucher
Series: Special Issue Neurosignals 2004
Publisher: Not Avail
Year: 2004
Language: English
Pages: 50
Contents......Page 4
Editorial......Page 5
Introduction......Page 6
Noxious Insults to the Developing Brain......Page 7
NMDA Receptors......Page 8
Under Normal Conditions......Page 9
Cell Death......Page 10
Animal Models Used to Study Changes in NMDA Receptors......Page 11
Substances of Abuse – Nicotine......Page 13
Therapeutic Interventions......Page 15
References......Page 16
Abstract......Page 19
NMDAR Subunits and Receptor Diversity......Page 20
Classical NMDARs......Page 21
Subunit Assembly and ER Export: Early Trafficking Checkpoints for NMDAR Surface Expression......Page 22
Developmental Plasticity and Changes in Synaptic NMDARs......Page 23
Experience- and Activity-Dependent Regulation of NMDARs......Page 26
Lateral Diffusion of Receptors between Synaptic and Extrasynaptic Sites......Page 27
Mechanisms of NMDAR Insertion......Page 28
NMDAR Internalization......Page 29
Acknowledgments......Page 30
References......Page 31
Introduction......Page 34
Posttranscriptional Regulation of NR1 Protein Expression in PC12 Cells......Page 35
Acknowledgments......Page 36
References......Page 37
Introduction......Page 38
Capping......Page 39
RNA Editing......Page 40
mRNA Domain Structure......Page 41
mRNA Stability......Page 42
Translation Initiation......Page 43
IRES (5'-UTR)......Page 45
NMDA Receptors......Page 46
References......Page 47
