A cutting-edge review of the latest findings on key scientific topics and the best strategies for evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of the various therapeutic choices available to the clinician managing patients with complicated portal hypertension.
Author(s): Arun J. Sanyal, Vijay H. Shah
Series: Clinical Gastroenterology
Edition: 1
Publisher: Humana Press
Year: 2005
Language: English
Pages: 513
A.pdf......Page 1
front-matter.pdf......Page 2
Part I.pdf......Page 14
1.01 Portal Hypertension.pdf......Page 15
Part II.pdf......Page 24
2.02 Anatomy and Vascular Biology of the Cells in the Portal Circulation.pdf......Page 25
2.03 Cell and Molecular Mechanisms of Increased Intrahepatic Resistance and Hemodynamic Correlates.pdf......Page 46
2.04 Molecular Mechanisms of Systemic Vasodilation and Hyperdynamic Circulatory State of Cirrhosis.pdf......Page 60
2.05 Mechanisms of Sodium Retention, Ascites Formation, and Renal Dysfunction in Cirrhosis.pdf......Page 74
2.06 Hepatic Hemodynamics in Portal Hypertension.pdf......Page 94
2.07 Neovascularization, Angiogenesis, and Vascular Remodeling in Portal Hypertension.pdf......Page 107
2.08 Mechanisms of Cardiopulmonary Hemodynamics and Dysfunction in Portal Hypertension.pdf......Page 121
Part III.pdf......Page 134
3.09 Measurement of Hepatic Venous Pressure Gradient.pdf......Page 135
3.10 Evaluation of Portal Hemodynamics Using Indicator Dilution and Noninvasive Techniques.pdf......Page 151
3.11 Endoscopic Assessment of Portal Hypertension Including Variceal Pressure Measurements.pdf......Page 161
Part IV.pdf......Page 171
4.12 Clinical Features and Natural History of Variceal Hemorrhage.pdf......Page 172
4.13 Management Strategies for the Prophylaxis and Treatment of Esophageal Variceal Rupture.pdf......Page 187
4.14 Pharmacologic Therapy for Management of Esophageal Varices.pdf......Page 203
4.15 Endoscopic Treatment for Bleeding Esophageal Varices.pdf......Page 224
4.16 Surgical Therapies for Management.pdf......Page 238
4.17 Transjugular Intrahepatic Portosystemic Stent-Shunt.pdf......Page 249
4.18 Clinical Features and Management of Gastric Varices, Portal Hypertensive Gastropathy, and Ectopic Varices.pdf......Page 269
Part V.pdf......Page 289
5.19 Ascites.pdf......Page 290
5.20 Management of Ascites.pdf......Page 305
5.21 Spontaneous Bacterial Peritonitis and Other Infections in Cirrhosis.pdf......Page 322
5.22 Diagnosis and Management of the Hepatorenal Syndrome.pdf......Page 345
Part VI.pdf......Page 365
6.23 Pregnancy and Portal Hypertension.pdf......Page 366
6.24 Causes and Management of Portal Hypertension in the Pediatric Population.pdf......Page 383
6.25 Noncirrhotic Portal Hypertension and Portal Vein Thrombosis.pdf......Page 411
6.26 Hepatic Venous Outflow Obstruction.pdf......Page 433
6.27 Pulmonary Complications Associated with Portal Hypertension.pdf......Page 454
6.28 Health Status Assessment and Economic Analyses in Cirrhosis and Portal Hypertension.pdf......Page 468
6.29 Future Treatments.pdf......Page 484
back-matter.pdf......Page 503
