This book focuses on the role of natural supplements in cancer prevention and therapy. The first section covers cancer epidemiology, cancer statistics and current therapies and potential toxicities involved with existing cancer drugs. The second section discusses the pathophysiology of cancer including mechanistic and molecular aspects of cancer biology, etiology of breast cancer, lung cancer, prostate cancer, tobacco and cancer, gastrointestinal tract cancers and various risk factors related to obesity, exercise and aging. The third section covers phytopharmaceuticals and focuses on cancer health risk factors and the protective abilities of the various natural products.
Author(s): Debasis Bagchi
Series: CRC series in modern nutrition science
Edition: 1
Publisher: CRC Press
Year: 2005
Language: English
Commentary: 68713
Pages: 840
City: Boca Raton, Fla
Contributors......Page 14
Table of Contents......Page 22
1 Epidemiology of Cancer: an Overview......Page 26
2 Role of DNA Methylation in Cancer and Chemotherapy......Page 43
3 Metals, Metalloids, and Cancer......Page 58
4 Molecular Mechanisms of Asbestos- and Silica-Induced Lung Cancer......Page 72
5 Involvement of Receptor Tyrosine Kinases in Lung Cancer: Clinical Importance......Page 98
6 Free Radicals, Environmental Radiation, and Cancer......Page 121
7 Smokeless Tobacco, Oxidative Stress, and Oral Cancer......Page 132
8 The Regulatory Roles of Estrogen in Carcinogenesis: an Overview......Page 152
9 Nonsteroidal Anti-Inflammatory Drugs (NSAID) and Colorectal Cancer......Page 179
10 Current Perspectives in Gastric Adenocarcinoma......Page 202
11 Adenocarcinoma of the Esophagus......Page 212
12 Helicobacter pylori and Gastric Cancer......Page 227
13 Free Radicals, Oxidative Stress, and Cancer......Page 237
14 Biotransformation and Mechanism of Action of Xenobiotics: What Lessons from the Past 40 Years?......Page 256
15 Obesity and Cancer......Page 266
16 Hemangioendothelioma as a Model to Study the Antiangiogenic Effects of Dietary Chemopreventive Agents In Vivo......Page 275
17 Modulation of Late Adverse Effects of Curative Radiation Therapy for Cancer......Page 286
18 Development of Selected Phytochemicals for Cancer Chemoprevention......Page 301
19 Phytochemicals as Potential Cancer Chemopreventive Agents......Page 311
20 History of Natural Supplements in Cancer Therapy and Prevention......Page 323
21 Vitamin C, Vitamin E, and β-Carotene in Cancer Chemoprevention......Page 352
22 Roles of Polyphenols, Flavonoids, and Oligomeric Proanthocyanidins in Cancer Chemoprevention......Page 399
23 Curcumin Derived from Turmeric (Curcuma longa): a Spice for All Seasons......Page 445
24 Tea in Chemoprevention of Cancer......Page 492
25 Phytoestrogens in Cancer Prevention: Characterization and Beneficial Effects of Kurarinone, a New Flavanone and a Major Phytoestrogen Constituent of Sophora flavescens Ait......Page 538
26 Resveratrol in the Chemoprevention and Chemotherapy of Breast Cancer......Page 566
27 Berries and Fruits in Cancer Chemoprevention*......Page 584
28 Palm Tocotrienols and Cancer......Page 601
29 Pycnogenol® in Cancer Chemoprevention......Page 614
30 Overview of the Use of Maitake Mushroom and Fraction D in Cancer......Page 636
31 Taxol in Cancer Treatment and Chemoprevention......Page 647
32 Lycopene and Cancer......Page 654
33 NADH in Cancer Prevention and Therapy......Page 674
34 Astaxanthin and Cancer Chemoprevention......Page 690
35 Chemopreventive Effects of Selected Spice Ingredients......Page 713
36 Coenzyme Q10 and Neoplasia: Overview of Experimental and Clinical Evidence*......Page 742
37 Probiotics in the Prevention of Cancer......Page 772
Commentary 1 Do Dietary Antioxidants Really Help Prevent or Treat Cancer?......Page 790
Commentary 2 Who Gets Cancer? Do Healthy Foods, Healthy Living, and Natural Antioxidants Really Help?......Page 795
Concluding Remarks......Page 798
Index......Page 799
