The gold standard text for the therapeutics course mandatory in pharmacy schools. Now in its sixth edition, this classic text continues its long-standing tradition of offering unparalleled guidance in the development of pharmaceutical care plans. The book provides a unique process of thinking about pharmacotherapy the process which uses evidence-based approaches to the drug treatment of diseases.
Features: *FREE Online Resource Center for professors and students - study materials, web chapters, questions and answers, and updates *NEW Key Concepts begin each chapter *Excellent use of algorithms, tables, and charts – provides clear recommendations *“Clinical Controversies” in the treatment sections of disease-oriented chapters
Author(s): Thomas C. Südhof, Klaus Starke
Series: Handbook of Experimental Pharmacology
Edition: 6
Publisher: McGraw-Hill Medical
Year: 2005
Language: English
Pages: 2847
Cover Page......Page 1
Notice......Page 3
Title Page......Page 4
ISBN 0071416137......Page 5
SECTION 2. CARDIOVASCULAR DISORDERS......Page 8
SECTION 4. GASTROINTESTINAL DISORDERS......Page 9
SECTION 7. PSYCHIATRIC DISORDERS.......Page 10
SECTION 9. GYNECOLOGIC AND OBSTETRIC DISORDERS......Page 11
SECTION 14. DERMATOLOGIC DISORDERS.......Page 12
SECTION 16. INFECTIOUS DISEASES......Page 13
SECTION 18. NUTRITIONAL DISORDERS.......Page 14
FOREWORD......Page 16
FOREWORD TO THE FIRST EDITION......Page 18
PREFACE......Page 20
CONTRIBUTORS......Page 22
GUIDING PRINCIPLES OF PHARMACOTHERAPY......Page 34
1. Pharmacoeconomics: Principles, Methods, and Applications......Page 38
2. Health Outcomes and Quality of Life......Page 54
3. Evidence-Based Medicine......Page 64
4. Documentation of Pharmacy Services......Page 76
5. Clinical Pharmacokinetics and Pharmacodynamics......Page 88
6. Pharmacogenetics......Page 112
7. Pediatrics......Page 128
8. Geriatrics......Page 140
9. Pharmacoepidemiology......Page 152
10. Clinical Toxicology......Page 162
11. Cardiovascular Testing......Page 186
12. Cardiopulmonary Resuscitation......Page 208
13. Hypertension......Page 222
14. Heart Failure......Page 256
15. Ischemic Heart Disease......Page 298
16. Acute Coronary Syndromes......Page 328
17. Arrhythmias......Page 358
18. Diastolic Heart Failure and the Cardiomyopathies......Page 394
19. Venous Thromboembolism......Page 410
20. Stroke......Page 452
21. Hyperlipidemia......Page 466
22. Peripheral Arterial Disease......Page 490
23. Use of Vasopressors and Inotropes in the Pharmacotherapy of Shock......Page 498
24. Hypovolemic Shock......Page 516
25. Introduction to Pulmonary Function Testing......Page 532
26. Asthma......Page 540
27. Chronic Obstructive Pulmonary Disease......Page 574
28. Acute Respiratory Distress Syndrome......Page 594
29. Drug-Induced Pulmonary Diseases......Page 614
30. Cystic Fibrosis......Page 628
31. Evaluation of the Gastrointestinal Tract......Page 642
32. Gastroesophageal Reflux Disease......Page 650
33. Peptic Ulcer Disease......Page 666
34. Inflammatory Bowel Disease......Page 686
35. Nausea and Vomiting......Page 702
36. Diarrhea, Constipation, and Irritable Bowel Syndrome......Page 714
37. Portal Hypertension and Cirrhosis......Page 730
38. Drug-Induced Liver Disease......Page 750
39. Pancreatitis......Page 758
40. Viral Hepatitis......Page 774
41. Quantification of Renal Function......Page 798
42. Acute Renal Failure......Page 818
43. Chronic Kidney Disease: Progression-Modifying Therapies......Page 836
44. Chronic Kidney Disease: Therapeutic Complications......Page 858
45. Hemodialysis and Peritoneal Dialysis......Page 888
46. Drug-Induced Kidney Disease......Page 908
47. Glomerulonephritis......Page 928
48. Drug Therapy Individualization for Patients with Renal Insufficiency......Page 956
49. Disorders of Sodium, Water, Calcium, and Phosphorus Homeostasis......Page 974
50. Disorders of Potassium and Magnesium Homeostasis......Page 1004
51. Acid-Base Disorders......Page 1020
52. Evaluation of Neurologic Illness......Page 1040
53. Multiple Sclerosis......Page 1044
54. Epilepsy......Page 1060
55. Status Epilepticus......Page 1086
56. Acute Management of the Brain Injury Patient......Page 1098
57. Parkinson's Disease......Page 1112
58. Pain Management......Page 1126
59. Headache Disorders......Page 1142
60. Evaluation of Psychiatric Illness......Page 1160
61. Childhood Disorders......Page 1170
62. Eating Disorders......Page 1184
63. Alzheimer's Disease......Page 1194
64. Substance-Related Disorders: Overview and Depressants, Stimulants, and Hallucinogens......Page 1212
65. Substance-Related Disorders: Alcohol, Nicotine, and Caffeine......Page 1230
66. Schizophrenia......Page 1246
67. Depressive Disorders......Page 1272
68. Bipolar Disorder......Page 1294
69. Anxiety Disorders I: Generalized Anxiety, Panic, and Social Anxiety Disorders......Page 1322
70. Anxiety Disorders II: Posttraumatic Stress Disorder and Obesessive-Compulsive Disorder......Page 1344
71. Sleep Disorders......Page 1358
72. Diabetes Mellitus......Page 1370
73. Thyroid Disorders......Page 1406
74. Adrenal Gland Disorders......Page 1428
75. Pituitary Gland Disorders......Page 1444
76. Pregnancy and Lactation: Therapeutic Considerations......Page 1462
77. Contraception......Page 1480
78. Menstruation-Related Disorders......Page 1502
79. Endometriosis......Page 1522
80. Hormone Therapy in Women......Page 1530
81. Erectile Dysfunction......Page 1552
82. Management of Benign Prostatic Hyperplasia......Page 1572
83. Urinary Incontinence......Page 1584
84. Function and Evaluation of the Immune System......Page 1602
85. Systemic Lupus Erythematosus and Other Collagen-Vascular Diseases......Page 1618
86. Allergic and Pseudoallergic Drug Reactions......Page 1636
87. Solid-Organ Transplantation......Page 1650
88. Osteoporosis and Osteomalacia......Page 1682
89. Rheumatoid Arthritis......Page 1708
90. Osteoarthritis......Page 1722
91. Gout and Hyperuricemia......Page 1742
92. Glaucoma......Page 1750
93. Allergic Rhinitis......Page 1766
94. Dermatologic Drug Reactions, Cancer......Page 1778
95. Acne Vulgaris......Page 1792
96. Psoriasis......Page 1806
97. Atopic Dermatitis......Page 1822
98. Hematopoiesis......Page 1830
99. Anemias......Page 1842
100. Coagulation Disorders......Page 1870
101. Sickle Cell Disease......Page 1892
102. Drug-Induced Hematologic Disorders......Page 1912
103. Laboratory Tests to Direct Antimicrobial Pharmacotherapy......Page 1928
104. Antimicrobial Regimen Selection......Page 1946
105. Central Nervous System Infections......Page 1960
106. Lower Respiratory Tract Infections......Page 1980
107. Upper Respiratory Tract Infections......Page 2000
108. Skin and Soft Tissue Infections......Page 2014
109. Infective Endocarditis......Page 2034
110. Tuberculosis......Page 2052
111. Gastrointestinal Infections and Enterotoxigenic Poisonings......Page 2072
112. Intraabdominal Infections......Page 2092
113. Parasitic Diseases......Page 2104
114. Urinary Tract Infections and Prostatitis......Page 2118
115. Sexually Transmitted Diseases......Page 2134
116. Bone and Joint Infections......Page 2156
117. Sepsis and Septic Shock......Page 2168
118. Superficial Fungal Infections......Page 2182
119. Invasive Fungal Infections......Page 2198
120. Infections in Immunocompromised Patients......Page 2228
121. Antimicrobial Prophylaxis in Surgery......Page 2254
122. Vaccines, Toxoids, and Other Immunobiologics......Page 2268
123. Human Immunodeficiency Virus Infection......Page 2292
124. Cancer Treatment and Chemotherapy......Page 2316
125. Breast Cancer......Page 2366
126. Lung Cancer......Page 2402
127. Colorectal Cancer......Page 2420
128. Prostate Cancer......Page 2458
129. Lymphomas......Page 2476
130. Ovarian Cancer......Page 2504
131. Acute Leukemias......Page 2522
132. Chronic Leukemias......Page 2550
133. Melanoma......Page 2562
134. Hematopoietic Stem Cell Transplantation......Page 2578
135. Assessment of Nutrition Status and Nutrition Requirements......Page 2596
136. Prevalence and Significance of Malnutrition......Page 2616
137. Parenteral Nutrition......Page 2628
138. Enteral Nutrition......Page 2652
139. Nutritional Considerations in Major Organ Failure......Page 2672
140. Obesity......Page 2696
Glossary......Page 2714
A......Page 2732
B......Page 2743
C......Page 2748
D......Page 2760
E......Page 2766
F......Page 2770
G......Page 2774
H......Page 2777
I......Page 2785
K......Page 2789
L......Page 2791
M......Page 2794
N......Page 2801
O......Page 2804
P......Page 2807
Q......Page 2818
R......Page 2819
S......Page 2821
T......Page 2828
U......Page 2834
V......Page 2835
Z......Page 2838
Color Plates......Page 2840
