Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs

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Finally - a book that covers all aspects of the illicit use of cocaine, amphetamines, ecstasy and/or designer drugs such as GHB, written by two experts in their field. The use of these drugs remains a continuous threat in health and medical care delivery, and this book will be an essential asset to the physician who may have to face the evaluation of patients whose use of these drugs compromises an effective treatment plan for other health issues.

The book has been conceived to fill the void in existing physician reference materials, and provides a comprehensive review of the theoretical knowledge and scope of pharmacotherapy in individuals who are hooked on a psychoactive substance.

While detailed scientific information is obtainable in other major articles, the book's straightforward format and style, along with its illustrations, will make for easy reading as emphasis is put on information specifically related to drugs that occur most abused in today’s society. The information provided is based on clinical practice rather than pure experimental data, which will give the physician more effective tools useful in their daily practice. Many mechanisms of action of abuse are described in detail and references are provided to direct the reader to further sources for additional information.

As a special feature, the book incorporates uncluttered tables and charts, which result in immediate clarification of the mode of action on the central nervous system and the reason for misuse, thus avoiding usual long and fatiguing text in common reference books. The book aims to give the reader a clear and concise plan on what to do when being faced with an overdose situation.

A well-organized Table of Contents rapidly leads the reader from general pharmacological issues to the specific overdose syndrome and its management. Additionally, significant emphasis is placed on the practical do's and don’ts for physicians, with special reference to the predictive signs of aberrant drug-related behavior and the identification of the drug diverter by using urine drug screening.

Author(s): Enno Freye
Edition: 1
Publisher: Springer
Year: 2010

Language: English
Pages: 300

Front Matter....Pages i-xi
Front Matter....Pages 5-8
Introduction....Pages 1-3
Production of the Coca Leaf....Pages 9-12
Cocaine: History of Use....Pages 13-18
Popularity of Cocaine as a Drug for Medical Treatment....Pages 19-25
The Different Types of Alkaloids in Coca....Pages 27-27
The Making of Cocaine in the Jungle....Pages 29-41
Freebase Cocaine: High Bioavailability with Increase in Potency....Pages 43-47
Pharmacology of Cocaine....Pages 49-60
Addictive Properties of Cocaine: Mode Of Action....Pages 61-64
Cocaine Intoxication: Strategy for Treatment....Pages 65-68
Special Pathologies in Chronic Cocaine Use....Pages 69-74
Summary of Advanced Treatment in Cocaine OD....Pages 75-77
Chronic Toxicity of Cocaine use....Pages 79-81
Summary of Acute-Chronic Effects of Cocaine....Pages 83-85
Cocaine Use in Pregnancy....Pages 87-97
Front Matter....Pages 109-114
New Options in the Treatment of Cocaine Dependency....Pages 99-108
Mode of Action of Methamphetamine....Pages 115-117
Pharmacology of Methamphetamine....Pages 119-124
Crystal Methamphetamine....Pages 125-129
Treatment Options in Methamphetamine Addiction and Withdrawal....Pages 131-133
Front Matter....Pages 109-114
Amphetamine Derivatives as Appetite Suppressants....Pages 135-137
Incidence of Illicit Use of Ecstasy....Pages 143-145
Pharmacology of Ecstasy (MDMA)....Pages 147-149
Pharmacological Effects of MDMA in Man....Pages 151-160
Pharmacokinetics of MDMA....Pages 161-172
Appendix....Pages 173-180
Front Matter....Pages 139-141
History of Designer Drugs....Pages 183-189
Gamma-Hydroxybutyric (GHB) Acid....Pages 191-194
The Pharmacology of γ-Hydroxybutyric Acid (GHB)....Pages 195-198
Use of GHB in Clinical Medicine....Pages 199-202
Abuse Potential and Intoxication with GHB....Pages 203-210
Benzylpiperazine (BZP) as a Designer Drug....Pages 211-213
Natural Products with Abuse Potential....Pages 215-215
Toxicity of Datura Stramonium....Pages 217-218
Dimethyltryptamine (DMT) a Psychedelic....Pages 219-220
The Mushroom Psilocybin with Psychedelic Properties....Pages 221-223
Ibogaine, Psychedelic Molecule with Anti-Addictive Properties....Pages 225-226
Peyote, a Mescaline-Containing Cactus....Pages 227-228
LSD, a Semisynthetic Psychedelic Drug....Pages 229-231
5-MeO-DIPT, a Psychedelic Structurally Related to Psiloc(yb)in....Pages 233-241
Front Matter....Pages 139-141
Positive Signs and Symptoms of Hard Drug Abuse....Pages 247-250
Urine Drug Screening (UDS): Identifying the Person with Illicit Use....Pages 251-252
Types of Urine Drug Testing....Pages 253-260
Front Matter....Pages 182-182
Type of Tests for Urine Drug Testing (UDT)....Pages 261-268
Front Matter....Pages 243-246
Analysis of Saliva, Hair and Sweat for Drug Testing....Pages 269-285
Back Matter....Pages 287-300