Extends the concepts of Volume 1 to include drug properties, design and optimization, coating and the effect of food and pharmacokinetics. This volume also reflects the growing interest in biodegradable polymers in oral and topical formulations and the use of sterile implants.
Author(s): James I. Wells, Michael H. Rubinstein
Series: Ellis Horwood Series in Pharmaceutical Technology
Edition: 1
Publisher: Ellis Horwood
Year: 1991
Language: English
Pages: 196
Book Cover......Page 1
Title......Page 4
Contents......Page 7
Influence of drug solubility in the formulation of hydrophobic matrices......Page 14
The effect of electrolytes and drugs on the cloud point of hydroxypropylmethylcellulose gels and the dissolution of drugs from hydroxypropylmethylcellulose matrix tablets......Page 24
Factors affecting the formulation of sustained release potassium chloride tablets......Page 34
Statistical optimization of a controlled release formulation obtained by a double-compression process: application of a Hadamard matrix and a factorial design......Page 44
Analysis of different parameters of an optimized prolonged release formulation obtained by five processes......Page 58
Controlled release matrix tablets of ketoprofen......Page 72
A new ibuprofen pulsed release oral dosage form......Page 80
Topical release and permeation studies of propanolol hydrochloride from hydrophilic polymeric matrices......Page 90
Polyacrylate (Eudragit retard) microspheres for oral controlled release of nifedipine: formulation design and process optimization......Page 104
Controlled delivery of theophylline from methacrylic ester copolymers and computer-supported pharmacokinetic assessment......Page 118
The effect of food on gastrointestinal transit and drug absorption of a multiparticular sustained release verapamil formulation......Page 126
Biodegradable polymers: effect of thermal treatment on the physicomechanical and dissolution properties of compacts......Page 132
A comparison of dissolution properties from matrix tablets prepared from microcapsules and mixtures containing phenobarbitone and poly(DL-lactic acid)......Page 142
In vitro-in vivo comparison of timolol maleate release from buffered and unbuffered matrices of monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride)......Page 156
Preparation and evaluation of a sustained release ophthalmic vehicle for dapiprazole......Page 162
Release kinetics of tobramycin sulphate from polymethylmethacrylate implants......Page 172
Formulation of silicone matrix systems for long-term constant release of peptides......Page 184
Index......Page 194
