Pharmaceutical Perspectives of Cancer Therapeutics presents a comprehensive yet easy-to-follow review of the principles, current progress and state-of-the-art of cancer therapeutics. The complexity of cancer demands an integrated understanding from both cancer biology and pharmaceutical dosage forms and drug delivery in order to warrant a successful therapeutic regimen. This book combines and merges the knowledge from these two aspects. Internationally acclaimed experts with a multi-disciplinary background, including scientists and clinicians from both academia and industries have contributed to this book to bridge the following areas between basic research and clinical application, pharmaceutical drug development processes and regulatory issues, drug design and delivery, laboratory and translational experimentation, marketing and postmarketing surveillance.
Main features of the book:
- Anticancer drug development and regulatory processes.
- Strategies to suppress tumor angiogenesis and metastasis, overcome multi-drug resistance in cancer, target telomerase and apoptosis pathways.
- Therapeutic approaches to employ monoclonal antibody and cancer vaccines.
- Introduction of new concepts such as cancer stem cells and new technologies such as nanobiotechnology, RNA interference, microRNA, and cancer cell gene profiling.
- Use of lipids, polymers and peptides for drug delivery and targeting to cancer cells or specific organs.
- Utilization of bioimaging and HIF-1 knockout animal models in cancer study.
- Clinical trials designs and principles
Author(s): Chikezie O. Madu, Yi Lu (auth.), Yi Lu, Ram I. Mahato (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2009
Language: English
Pages: 694
Tags: Cancer Research
Front Matter....Pages i-xvi
Tumor Microvasculature and Microenvironment: Therapeutic Targets for Inhibition of Tumor Angiogenesis and Metastasis....Pages 1-47
Anticancer Drug Development....Pages 49-92
Tumor-Targeted Macromolecular Drug Delivery Based on the Enhanced Permeability and Retention Effect in Solid Tumor....Pages 93-120
Multidrug Resistance in Solid Tumor and Its Reversal....Pages 121-148
Targeting of Apoptosis Signaling Pathways and Their Mediators for Cancer Therapy....Pages 149-188
Role of Telomerase in Cancer Therapeutics....Pages 189-205
Polymeric Carriers for Anticancer Drugs....Pages 207-243
Application of Nanobiotechnology in Cancer Therapeutics....Pages 245-268
Receptor-Mediated Delivery of Proteins and Peptides to Tumors....Pages 269-295
Protein Transduction Domain-Mediated Delivery of Anticancer Proteins....Pages 297-319
Pharmaceutical Perspectives of Cancer Therapeutics: Current Therapeutic Uses of Monoclonal Antibodies....Pages 321-363
Cancer Vaccines....Pages 365-397
RNA Interference for Cancer Therapy....Pages 399-440
MicroRNAs as Therapeutic Targets for Cancer....Pages 441-474
Targeted Therapies for Malignant Brain Tumors....Pages 475-519
The Complexity of the HIF-1-Dependent Hypoxic Response in Breast Cancer Presents Multiple Avenues for Therapeutic Intervention....Pages 521-558
Cancer Stem Cells: Potential Mediators of Therapeutic Resistance and Novel Targets of Anti-cancer Treatments....Pages 559-579
Image-Guided Photodynamic Cancer Therapy....Pages 581-599
Functional Imaging of Multidrug Resistance and Its Applications....Pages 601-643
Gene Expression Microarrays in Cancer Research....Pages 645-672
Clinical Trials and Translational Applications in Cancer Therapy....Pages 673-683
Back Matter....Pages 685-693
