Pharmaceutical Calculations: A Conceptual Approach, is a book that combines conceptual and procedural understanding for students and will guide you to master prerequisite skills to carry out accurate compounding and dosage regimen calculations. It is a book that makes the connection between basic sciences and pharmacy. It describes the most important concepts in pharmaceutical sciences thoroughly, accurately and consistently through various commentaries and activities to make you a scientific thinker, and to help you succeed in college and licensure exams. Calculation of the error associated with a dose measurement can only be carried out after understanding the concept of accuracy versus precision in a measurement. Similarly, full appreciation of drug absorption and distribution to tissues can only come about after understanding the process of transmembrane passive diffusion. Early understanding of these concepts will allow reinforcement and deeper comprehension of other related concepts taught in other courses. More weight is placed on the qualitative understanding of fundamental concepts, like tonicity vs osmotic pressure, diffusion vs osmosis, crystalloids vs colloids, osmotic diuretics vs plasma expanders, rate of change vs rate constants, drug accumulation vs drug fluctuation, loading dose vs maintenance dose, body surface area (BSA) vs body weight (BW) as methods to adjust dosages, and much more, before considering other quantitative problems. In one more significant innovation, the origin and physical significance of all final forms of critical equations is always described in detail, thus, allowing recognition of the real application and limitations of an equation. Specific strategies are explained step-by-step in more than 100 practice examples taken from the fields of compounding pharmacy, pharmaceutics, pharmacokinetics, pharmacology and medicine.
Author(s): Michalakis Savva
Publisher: Springer
Year: 2019
Language: English
Pages: 378
Tags: Pharmaceutical Sciences / Technology, Pharmaceutical Calculations
Front Matter ....Pages i-xvii
Measurement (Michalakis Savva)....Pages 1-18
Error Assessment of Drug Dose in Pharmaceutical Mixtures (Michalakis Savva)....Pages 19-53
Density and Specific Gravity (Michalakis Savva)....Pages 55-60
Units of Concentration and the Salt Factor (Michalakis Savva)....Pages 61-92
Dilution and Concentration of Pharmaceutical Solutions and Other Physical Mixtures (Michalakis Savva)....Pages 93-112
Mixture Problems in Pharmaceutical Sciences (Michalakis Savva)....Pages 113-155
Isotonic Solutions (Michalakis Savva)....Pages 157-180
Diffusion (Michalakis Savva)....Pages 181-208
Use of Prefabricated Dosage Forms in Extemporaneous Compounding (Michalakis Savva)....Pages 209-218
Fluids and Electrolytes (Michalakis Savva)....Pages 219-249
Essential Mathematics for Pharmacokinetics (Michalakis Savva)....Pages 251-268
Rates and Orders of Reactions (Michalakis Savva)....Pages 269-299
Fundamental Concepts of Dosage Calculations (Michalakis Savva)....Pages 301-327
Dosage Calculations Based on Body Surface Area (BSA) (Michalakis Savva)....Pages 329-342
Intravenous Infusion and Flow Rate (Michalakis Savva)....Pages 343-352
Back Matter ....Pages 353-369