Content: Metabolism of organophosphorus insecticides in aquatic organisms, with special emphasis on fenitrothion / Junshi Miyamoto, Yoshiyuki Takimoto, and Kazumasa Mihara --
Disposition of polychlorinated biphenyls in fish / Richard E. Peterson and Patrick D. Guiney --
Metabolism of cyclodiene insecticides by fish / M.A.Q. Khan, M. Feroz, and P. Sudershan --
Disposition and metabolism of aromatic hydrocarbons in marine organisms / Donald C. Malins, Tracy K. Collier, and Herbert R. Sanborn --
Metabolism of phthalate esters in aquatic species / Mark J. Melancon --
Metabolism of the thiocarbamate herbicide molinate (Ordram) in Japanese carp / Ming-Muh Lay, Ann M. Niland, J.R. Debaun, Julius J. Menn, and C.K. Tseng --
Biotransformation of selected chemicals by fish / John L. Allen, Verdel K. Dawson, and Joseph B. Hunn --
Metabolism of pentachlorophenol in fish / Kunio Kobayashi --
The disposition and biotransformation of organochlorine insecticides in insecticide-resistant and -susceptible mosquitofish / James D. Yarbrough and Janice E. Chambers --
Metabolism of insect growth regulators in aquatic organisms / David A. Schooley and Gary R. Quistad --
The fate of highly brominated aromatic hydrocarbons in fish / V. Zitko --
A terrestrial-aquatic model ecosystem for evaluating the environmental fate of drugs and related residues in animal excreta / S.H. Caballa, M. Patterson, and I.P. Kapoor --
Modeling aquatic ecosystems for metabolic studies / Allan R. Isensee, Philip C. Kearney, and Gerald E. Jones --
Investigation of xenobiotic metabolism in intact aquatic animals / D.G. Crosby, P.F. Landrum, and C.C. Fischer --
Xenobiotic transport mechanisms and pharmacokinetics in the dogfish shark / A.M. Guarino and S.T. Arnold --
Disposition of toxic substances in mussels (Mytilus califorianus) : preliminary metabolic and histologic studies / Robert I. Krieger, Shirley J. Gee, Lori O. Lim, John H. Ross, Anne Wilson, Charles Alpers, and Sefton R. Wellings --
Cytochrome P-450 in fish liver microsomes and carcinogen activation / Jorma T. Ahokas --
Microsomal mixed-function oxidation in untreated and polycyclic aromatic hydrocarbon-treated marine fish / John R. Bend, Louise M. Ball, Tahani H. Elmamlouk, Margaret O. James, and Richard M. Philpot --
Induction of hepatic microsomal enzymes in rainbow trout / Clifford R. Elcombe, Ronald B. Franklin, and John J. Lech --
Further studies on the effect of petroleum hydrocarbons on mixed-function oxidases in marine organisms / Jerry F. Payne and Nancy May --
In vivo and in vitro studies of mixed-function oxidase in an aquatic insect, Chironomus riparius / J.F. Estenik and W.J. Collins --
Degradation of pesticides by algae and aquatic microorganisms / F. Matsumura and E.G. Esaac --
Dietary casein levels and aflatoxin B1 metabolism in rainbow trout (Salmo gairdneri) / W.T. Stott and R.O. Sinnhuber --
Alterations in rainbow trout liver function and body fluids following treatment with carbon tetrachloride or monochlorobenzene / Lavern J. Weber, William H. Gingerich, and Keith F. Pfeifer.
Author(s): M. A. Q. Khan, John J. Lech, and Julius J. Menn (Eds.)
Series: ACS Symposium Series 99
Publisher: American Chemical Society
Year: 1979
Language: English
Pages: 430
Title Page......Page 1
Half Title Page......Page 3
Copyright......Page 4
ACS Symposium Series......Page 5
FOREWORD......Page 6
PdftkEmptyString......Page 0
PREFACE......Page 7
Metabolism in vitro......Page 10
Metabolism and bioaccumulation in vivo......Page 12
Translocation and transformation in a freshwater model ecosystem......Page 17
Literature Cited......Page 26
2 Disposition of Polychlorinated Biphenyls in Fish......Page 28
Literature Cited......Page 42
3 Metabolism of Cyclodiene Insecticides by Fish......Page 44
(ii) Elimination......Page 46
(iii) Metabolism......Page 47
(i) Absorption......Page 48
(iii) Metabolism......Page 50
Literature Cited......Page 62
INCORPORATION OF HYDROCARBONS INTO TISSUES AND BODY FLUIDS......Page 64
BIOTRANSFORMATIONS......Page 71
CONCLUSIONS......Page 78
LITERATURE CITED......Page 80
Metabolism of Phthalate Esters by Microorganisms......Page 83
Metabolism of Phthalate Esters by Fishin vitro......Page 85
Other Studies of the Metabolism of Phthalate Esters by Aquatic Species......Page 95
Acknowledgements......Page 98
Literature Cited......Page 99
Material and Methods......Page 101
Results and Discussion......Page 104
Acknowledgement......Page 122
Literature Cited......Page 124
7 Biotransformation of Selected Chemicals by Fish......Page 126
Glucuronide Conjugation......Page 127
Acetylation......Page 129
N-Dealkylation......Page 130
S-Methylation......Page 131
Literature Cited......Page 132
Toxicity of PCP and Other Chlorophenols......Page 135
Biliary Excretion of PCP-glucuronide......Page 137
Renal Excretion of PCP-sulfate......Page 138
Whole View of Major Detoxification Pathways for PCP......Page 140
Effect of Pre-exposure to PCP on PCP-tolerance and Sulfate Conjugation Activity......Page 143
Literature Cited......Page 147
9 The Disposition and Biotransformation of Organochlorine Insecticides in Insecticide-Resistant and -Susceptible Mosquitofish......Page 148
Disposition......Page 149
Biotransformation......Page 153
Discussion......Page 159
Abstract......Page 160
Literature Cited......Page 161
Diflubenzuron......Page 163
Epifenonane......Page 167
Methoprene......Page 171
Literature Cited......Page 176
11 The Fate of Highly Brominated Aromatic Hydrocarbons in Fish......Page 179
Experimental......Page 180
Results and Discussion......Page 181
Literature Cited......Page 183
Materials and Methods......Page 185
Results and Discussion......Page 188
Literature Cited......Page 196
Chemicals and Experimental Chambers......Page 197
Results and Discussion......Page 202
Abstract......Page 217
Literature cited......Page 218
14 Investigation of Xenobiotic Metabolism in Intact Aquatic Animals......Page 219
Laboratory Metabolism Chambers......Page 220
Aquatic Metabolism Protocol......Page 223
p-Nitroanisole Pharmacodynamics in the Sea Urchin......Page 225
Conclusions......Page 229
Literature Cited......Page 232
15 Xenobiotic Transport Mechanisms and Pharmacokinetics in the Dogfish Shark......Page 234
Handling Advantages of the Dogfish Shark......Page 235
Initial Studies with the Model Compound Phenol Red......Page 241
Disposition of Phenol Red......Page 242
Effects of Interrupted Enterohepatic Circulation on Biliary and Urinary Handling of Phenol Red......Page 243
Concentrated Transfer of Phenol Red into Renal and Hepatic Compartments......Page 245
Saturation of Excretory Processes......Page 246
Inhibition of Phenol Red Execretion by Probenecid......Page 247
Plasma Binding of Phenol Red......Page 248
Distribution and Pharmacokinetics of Water Soluble Compounds......Page 251
Distribution and Pharmacokinetics of Lipophilic Pollutants......Page 252
Distribution and Pharmacokinetics of Metallic Compounds......Page 256
Literature Cited......Page 257
16 Disposition of Toxic Substances in Mussels (Mytiluscaliforianus): Preliminary Metabolic and Histologic Studies......Page 260
Methods and Materials......Page 261
Results......Page 263
Literature Cited......Page 277
Cytochrome P-450 mediated monooxygenase......Page 279
Active metabolites and carcinogenicity......Page 286
Conclusions......Page 290
Literature Cited......Page 291
18 Microsomal Mixed-Function Oxidation in Untreated and Polycyclic Aromatic Hydrocarbon-Treated Marine Fish......Page 297
Materials and Methods......Page 298
Results and Discussion......Page 301
Literature Cited......Page 315
19 Induction of Hepatic Microsomal Enzymes in Rainbow Trout......Page 319
Materials and Methods......Page 320
Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)......Page 321
Results and Discussion......Page 322
Literature Cited......Page 333
20 Further Studies on the Effect of Petroleum Hydrocarbons on Mixed-Function Oxidases in Marine Organisms......Page 338
Attempts to Induce AHH in Invertebrates under Extreme Oil Exposure Conditions......Page 339
Induction of Bivalve MFO......Page 341
Induction of Fish AHH with Pure Hydrocarbons......Page 342
Induction of AHH in Fish with Oil and Oil Spill Dispersant Mixtures......Page 343
Conclusions......Page 344
Literature Cited......Page 345
Introduction......Page 347
Materials and Methods......Page 348
Results......Page 351
Discussion......Page 361
Acknowledgement......Page 366
Literature Cited......Page 367
22 Degradation of Pesticides by Algae and Aquatic Microorganisms......Page 369
Experimental......Page 370
Results......Page 371
Discussion......Page 382
Literature Cited.......Page 384
23 Dietary Case in Levels and Aflatoxin B1 Metabolism in Rainbow Trout (Salmo gairdneri)......Page 386
Experimental Procedures......Page 387
Results and Discussion......Page 389
Literature Cited......Page 395
24 Alterations in Rainbow Trout Liver Function and Body Fluids Following Treatment with Carbon Tetrachloride or Monochlorobenzene......Page 398
Materials and Methods......Page 399
Results......Page 400
Discussion......Page 405
Literature Cited......Page 409
A......Page 411
Β......Page 412
C......Page 413
D......Page 415
E......Page 416
G......Page 417
H......Page 418
I......Page 419
L......Page 420
M......Page 421
Ν......Page 423
P......Page 424
R......Page 426
S......Page 427
Τ......Page 428
W......Page 429
X......Page 430
