Peptide-Based Drug Design

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Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biology™ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls.

Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.

Author(s): Laszlo Otvos Jr. (auth.), Laszlo Otvos (eds.)
Series: Methods In Molecular Biology 494
Edition: 1
Publisher: Humana Press
Year: 2008

Language: English
Pages: 303
Tags: Pharmacology/Toxicology; Medicinal Chemistry

Front Matter....Pages i-xi
Back Matter....Pages 1-8
....Pages 9-29