Pediatric Psychopharmacology: Principles and Practice is an authoritative and comprehensive text on the use of medication in the treatment of children and adolescents with serious neuropsychiatric disorders. This benchmark volume consists of 56 chapters written by internationally recognized leaders, and is divided into four interrelated sections. The first, Biological Bases of Pediatric Psychopharmacology, reviews key principles of neurobiology and the major psychiatric illnesses of childhood from a perspective rooted in developmental psychopathology. The second, Somatic Interventions, presents the major classes of psychiatric drugs, as well as complementary and alternative somatic interventions, such as electroconvulsive therapy (ECT), transcranial magnetic stimulation (rTMS), and naturopathic approaches. The third and longest section, Assessment and Treatment,starts with clinical assessment, diagnostic evaluation, and comprehensive treatment planning, and goes on to cover the evidence-based analysis of drug treatments for the major disorders. Special populations (such as children with comorbid mental retardation, substance abuse or medical illness) are specifically discussed, and the coordination of their treatment with non-somatic therapies is explicitly addressed. The final section, Epidemiologic, Research, and Methodological Considerations, deals with broad population-relevant topics such as regulation and policy, pharmacoepidemiology, and the critical importance of sound ethical principles for clinical investigation. The book concludes with an appendix on generic and commercial drug name equivalencies, preparations, and available dosages. This timely text is intended for child and adolescent psychiatrists, general and developmental pediatricians, family practitioners, general psychiatrists, and other mental health professionals who work with children and adolescents.
Author(s): Andres Martin, Lawrence Scahill, Dennis S. Charney, James F. Leckman
Edition: 1
Publisher: Oxford University Press, USA
Year: 2002
Language: English
Pages: 814
Contents......Page 12
Contributors......Page 16
SECTION I: BIOLOGICAL BASES OF PEDIATRIC PSYCHOPHARMACOLOGY......Page 22
I-A: DEVELOPMENTAL PRINCIPLES OF NEUROBIOLOGY AND PSYCHOPHARMACOLOGY......Page 24
1. Overview of Brain Development......Page 26
2. Synaptic Function and Biochemical Neuroanatomy......Page 43
3. Mechanisms of Signal Transduction and Adaptation to Psychotropic Drug Action......Page 56
4. Pharmacokinetics I: Developmental Principles......Page 67
5. Pharmacokinetics II: Cytochrome P450–Mediated Drug Interactions......Page 77
I-B: GENETIC PRINCIPLES......Page 90
6. Molecular Genetics......Page 92
7. Pharmacogenetics......Page 107
I-C: DEVELOPMENTAL PSYCHOPATHOLOGY......Page 120
8. Neurobiology of Attention Regulation and its Disorders......Page 122
9. Neurobiology of Early-Life Stress and its Disorders......Page 133
10. Neurobiology of Early-Onset Mood Disorders......Page 147
11. Neurobiology of Early-Onset Anxiety Disorders......Page 161
12. Neurobiology of Obsessive-Compulsive Disorder......Page 173
13. Neurobiology of Tic Disorders, Including Tourette’s Syndrome......Page 187
14. Neurobiology of Immune-Mediated Neuropsychiatric Disorders......Page 198
15. Neurobiology of Childhood Schizophrenia and Related Disorders......Page 207
16. Neurobiology of Affiliation: Implications for Autism Spectrum Disorders......Page 218
17. Neurobiology of Aggression......Page 233
18. Neurobiology of Eating Disorders......Page 247
19. Neurobiology of Substance Abuse and Dependence Disorders......Page 261
SECTION II: SOMATIC INTERVENTIONS......Page 274
II-A: PSYCHOTROPIC AGENTS......Page 276
20. Stimulants......Page 278
21. Adrenergic Agonists: Clonidine and Guanfacine......Page 287
22. Antidepressants I: Selective Serotonin Reuptake Inhibitors......Page 297
23. Antidepressants II: Tricyclic Agents......Page 307
24. Antidepressants III: Other Agents......Page 318
25. Mood Stabilizers: Lithium and Anticonvulsants......Page 332
26. Antipsychotic Agents: Traditional and Atypical......Page 351
27. Anxiolytics: Benzodiazepines, Buspirone, and Others......Page 364
28. Miscellaneous Compounds: Beta-Blockers and Opiate Antagonists......Page 376
II-B: OTHER SOMATIC INTERVENTIONS......Page 386
29. Complementary and Alternative Medicine in Pediatric Psychopharmacology......Page 388
30. Electroconvulsive Therapy and Transcranial Magnetic Stimulation......Page 400
SECTION III: ASSESSMENT AND TREATMENT......Page 410
III-A: GENERAL PRINCIPLES......Page 412
31. Clinical Assessment of Children and Adolescents Treated Pharmacologically......Page 414
32. Clinical Instruments and Scales in Pediatric Psychopharmacology......Page 427
33. Thinking About Prescribing: The Psychology of Psychopharmacology......Page 440
34. Combining Pharmacotherapy and Psychotherapy: An Evidence-Based Approach......Page 449
III-B: SPECIFIC DISORDERS AND SYNDROMES......Page 468
35. Attention-Deficit Hyperactivity Disorder......Page 470
36. Depressive Disorders......Page 489
37. Bipolar Disorder......Page 507
38. Anxiety Disorders......Page 520
39. Obsessive-Compulsive Disorder......Page 534
40. Tourette’s Syndrome and Other Tic Disorders......Page 549
41. Early-Onset Schizophrenia......Page 566
42. Autistic and Other Pervasive Developmental Disorders......Page 586
43. Post-traumatic Stress Disorder......Page 603
44. Eating Disorders......Page 615
III-C: SPECIAL CLINICAL POPULATIONS......Page 626
45. Substance-Abusing Youths......Page 628
46. Individuals with Mental Retardation......Page 640
47. The Medically Ill Child or Adolescent......Page 654
48. Psychopharmacology During Pregnancy: Infant Considerations......Page 665
49. Psychopharmacological Treatment of Preschoolers......Page 677
III-D: OTHER AREAS OF CLINICAL CONCERN......Page 692
50. Agitation and Aggression......Page 694
51. Elimination Disorders: Enuresis and Encopresis......Page 709
SECTION IV: EPIDEMIOLOGICAL, RESEARCH, AND METHODOLOGICAL CONSIDERATIONS......Page 722
52. Pediatric Psychopharmacoepidemiology: Who Is Prescribing? And For Whom, How, and Why?......Page 724
53. Clinical Trials Methodology and Design Issues......Page 735
54. Regulatory Issues......Page 748
55. Ethical Issues in Research......Page 760
56. International Perspectives......Page 769
Appendix: Pediatric Psychopharmacology at a Glance......Page 780
A......Page 788
B......Page 791
C......Page 793
D......Page 796
E......Page 797
F......Page 798
G......Page 799
I......Page 800
L......Page 801
M......Page 802
N......Page 804
O......Page 805
P......Page 806
R......Page 808
S......Page 809
T......Page 812
V......Page 813
Z......Page 814
