Childhood obesity and its co-morbidities -- including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, and fatty liver disease -- have seen striking increases in recent years. Despite a wealth of investigation, there is considerable controversy regarding the etiology of childhood obesity and the optimal approaches for prevention and treatment. Pediatric Obesity: Etiology, Pathogenesis, and Treatment addresses the controversy with a range of features that make it a unique resource for those who care for obese children and their families. Written from a perspective that is international in scope, the distinguished authors re-assess the roles of genetic and environmental factors in the pathogenesis of childhood obesity and critically review new studies of the effects of lifestyle, pharmacologic, and surgical interventions. The evidence-based approach of Pediatric Obesity: Etiology, Pathogenesis, and Treatment provides a comprehensive and invaluable guide for all healthcare providers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic.
Author(s): Barry Popkin (auth.), Michael Freemark (eds.)
Series: Contemporary Endocrinology
Edition: 1
Publisher: Humana Press
Year: 2010
Language: English
Pages: 487
Tags: Endocrinology; General Practice / Family Medicine; Internal Medicine
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Global Dynamics in Childhood Obesity: Reflections on a Life of Work in the Field....Pages 3-11
Front Matter....Pages 13-13
The Neuroendocrine Control of Energy Balance....Pages 15-32
Front Matter....Pages 33-33
Monogenic Obesity....Pages 35-45
Syndromic Obesity....Pages 47-64
Polygenic Obesity....Pages 65-73
Racial Differences in Childhood Obesity: Pathogenesis and Complications....Pages 75-89
Front Matter....Pages 91-91
Maternal Determinants of Childhood Obesity: Weight Gain, Smoking, and Breastfeeding....Pages 93-102
Intrauterine Growth Retardation....Pages 103-112
Gestational Diabetes....Pages 113-122
Front Matter....Pages 123-123
The Role of Diet....Pages 125-135
Energy Expenditure in Children: The Role of NEAT ....Pages 137-151
Front Matter....Pages 153-153
Childhood Obesity and the Regulation of Growth, Thyroid Function, Sexual Development, and Calcium Homeostasis....Pages 155-162
Pathogenesis of Insulin Resistance and Glucose Intolerance in Childhood Obesity....Pages 163-174
Pathogenesis and Management of Dyslipidemia in Obese Children....Pages 175-199
Fatty Liver Disease....Pages 201-222
Pathogenesis of Hypertension and Renal Disease in Obesity....Pages 223-239
Sleep-Disordered Breathing and Sleep Duration in Childhood Obesity....Pages 241-252
The Long-Term Metabolic Complications of Childhood Obesity....Pages 253-263
Childhood Obesity, Atherogenesis, and Adult Cardiovascular Disease....Pages 265-278
Front Matter....Pages 279-279
Family-Based Behavioral Interventions....Pages 281-301
Front Matter....Pages 279-279
Exercise and Childhood Obesity....Pages 303-313
School- and Community-Based Interventions....Pages 315-335
Front Matter....Pages 337-337
Pharmacotherapy of Childhood Obesity and Pre-diabetes....Pages 339-355
Pathogenesis and Management of Adiposity and Insulin Resistance in PCOS: Prevention and Treatment of the Metabolic Disease Components....Pages 357-367
Obesity and Metabolic Dysfunction in the Child with a Major Behavioral Disorder: Atypical Antipsychotics....Pages 369-376
Hypothalamic Obesity....Pages 377-388
Bariatric Surgery in Adolescents....Pages 389-402
Front Matter....Pages 403-403
Neuroendocrine and Metabolic Adaptations in the Central Nervous System That Facilitate Weight Regain....Pages 405-421
The Socio-cultural Context for Obesity Prevention and Treatment in Children and Adolescents: Influences of Ethnicity and Gender....Pages 423-436
Front Matter....Pages 437-437
The Marketing and Distribution of Fast Food....Pages 439-450
Local and National Policy-Based Interventions: To Improve Children’s Nutrition....Pages 451-460
Back Matter....Pages 461-487
