Pediatric and Adolescent Osteosarcoma provides a review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. It outlines concepts in epidemiology and etiology, and provides chapters on pathology and radiologic characteristics of osteosarcoma, surgical therapy tailored specifically for treatment of primary tumors in pediatric/adolescent age groups, treatment of pulmonary and extra pulmonary metastases and complications, as well as the role of radiation therapy. The volume concludes with a review of differences and similarities in the management of osteosarcoma in adults as compared to pediatrics / adolescents and new laboratory and animal investigations currently in progress to develop effective diagnostic and therapeutic approaches to improve the outcome.
In essence the scope and intensive coverage of the book provides a historical perspective of the advances made over the past 30 years and emerging concepts and prospects for new diagnostic and therapeutic approaches. This is based upon past experiences and new discoveries. It also provides a unique opportunity for pediatric and adult medical oncologists, physicians in training, orthopedic surgeons, pathologists, radiologists, radiotherapists, oncology nurses and allied professionals involved in the care of pediatric/adolescent patients with osteosarcoma to become acquainted with prevailing methods of treatment and new and evolving concepts and developments.
"Osteosarcoma is the most common primary bone malignancy. Remarkable advances have occurred in the management of this cancer over the last two decades. In this text experts in the field discuss the most pertinent biologic and clinical issues relevant to the disease."
Steven T. Rosen, M.D.
Series Editor
Author(s): Giulia Ottaviani, Norman Jaffe (auth.), Norman Jaffe, Oyvind S. Bruland, Stefan Bielack (eds.)
Series: Cancer Treatment and Research 152
Edition: 1
Publisher: Springer US
Year: 2010
Language: English
Pages: 592
Tags: Oncology; Pediatrics
Front Matter....Pages i-xx
Front Matter....Pages 1-1
The Epidemiology of Osteosarcoma....Pages 3-13
The Etiology of Osteosarcoma....Pages 15-32
Imaging Assessment of Osteosarcoma in Childhood and Adolescence: Diagnosis, Staging, and Evaluating Response to Chemotherapy....Pages 33-62
Osteosarcoma Multidisciplinary Approach to the Management from the Pathologist’s Perspective....Pages 63-84
Conditions that Mimic Osteosarcoma....Pages 85-121
Front Matter....Pages 124-124
Surgical Management of Primary Osteosarcoma....Pages 125-145
The Role of Radiotherapy in Oseosarcoma....Pages 147-164
Osteosarcoma Lung Metastases Detection and Principles of Multimodal Therapy....Pages 165-184
Surgical Treatment of Pulmonary Metastases from Osteosarcoma in Pediatric and Adolescent Patients....Pages 185-201
Non-Surgical Treatment of Pulmonary and Extra-pulmonary Metastases....Pages 203-215
Front Matter....Pages 218-218
Adjuvant Chemotherapy in Osteosarcoma....Pages 219-237
Osteosarcoma: Review of the Past, Impact on the Future. The American Experience....Pages 239-262
Osteosarcoma: The European Osteosarcoma Intergroup (EOI) Perspective....Pages 263-274
The Treatment of Nonmetastatic High Grade Osteosarcoma of the Extremity: Review of the Italian Rizzoli Experience. Impact on the Future....Pages 275-287
Osteosarcoma: The COSS Experience....Pages 289-308
Treatment of Osteosarcoma. The Scandinavian Sarcoma Group Experience....Pages 309-318
Childhood Osteosarcoma: Multimodal Therapy in a Single-Institution Turkish Series....Pages 319-338
International Collaboration is Feasible in Trials for Rare Conditions: The EURAMOS Experience....Pages 339-353
Pediatric and Adult Osteosarcoma: Comparisons and Contrasts in Presentation and Therapy....Pages 355-363
Front Matter....Pages 366-366
The Role of Physical Therapy and Occupational Therapy in the Rehabilitation of Pediatric and Adolescent Patients with Osteosarcoma....Pages 367-384
Front Matter....Pages 366-366
Caring for Children and Adolescents with Osteosarcoma: A Nursing Perspective....Pages 385-394
Prosthetics for Pediatric and Adolescent Amputees....Pages 395-420
Functional, Psychosocial and Professional Outcomes in Long-Term Survivors of Lower-Extremity Osteosarcomas: Amputation Versus Limb Salvage....Pages 421-436
Front Matter....Pages 438-438
Bridging the Gap Between Experimental Animals and Humans in Osteosarcoma....Pages 439-446
Is There a Role for Immunotherapy in Osteosarcoma?....Pages 447-457
Molecular Classification of Osteosarcoma....Pages 459-465
Current Concepts on the Molecular Biology of Osteosarcoma....Pages 467-478
How the NOTCH Pathway Contributes to the Ability of Osteosarcoma Cells to Metastasize....Pages 479-496
The Role of Fas/FasL in the Metastatic Potential of Osteosarcoma and Targeting this Pathway for the Treatment of Osteosarcoma Lung Metastases....Pages 497-508
Bone Marrow Micrometastases Studied by an Immunomagnetic Isolation Procedure in Extremity Localized Non-metastatic Osteosarcoma Patients....Pages 509-515
Strategies to Explore New Approaches in the Investigation and Treatment of Osteosarcoma....Pages 517-528
History of Orthopedic Oncology in the United States....Pages 529-571
Back Matter....Pages 573-591
