Over the last few years there have been huge advances made in our understanding of the interactions between the brain and the gut – the enteric nervous system. This book is particularly relevant in the understanding, diagnosis and management of irritable bowel syndrome – the most common functional disorder of the bowel. IBS has been diagnosed in 10-20% of adults in the US, and symptoms of IBS are responsible for more than 3 million visits to the physician in the US.This book is aimed at specialist gastroenterologists but also should be of interest for trainees and fellows in gastroenterology, as well as PCPs and GPs with an interest in this subject.
Author(s): Robin Spiller, David Grundy
Edition: 1
Publisher: Wiley-Blackwell
Year: 2004
Language: English
Pages: 273
Pathophysiology of the Enteric Nervous System......Page 2
Contents......Page 8
Contributors......Page 10
Preface......Page 12
Section A Basic Principles......Page 13
1 Functional Neuroanatomy......Page 15
2 Neurophysiology......Page 25
3 Gut-to-Brain Signaling: Sensory Mechanisms......Page 36
4 Brain-to-Gut Signaling: Central Processing......Page 46
Section B Mechanisms of Functional Gastrointestinal Disorders......Page 57
5 Developmental Disorders......Page 59
6 Inflammation......Page 73
7 Stress and the Gut: Central Influences......Page 91
8 Stress and the Gut: Peripheral Effects......Page 102
Section C Pathophysiology and Treatment of Human Diseases......Page 115
9 Esophageal Disorders......Page 117
10 Gastric Disorders......Page 138
11 Small Bowel Disorders......Page 146
12 Colonic Disorders......Page 159
13 Anorectal Disorders......Page 173
14 Central Nervous System Injury......Page 188
15 Diarrhoea-Predominant Bowel Disorders Following Inflammation and Infection......Page 200
Section D Advances in Pharmacotherapy......Page 213
16 Functional Targets for Pharmacotherapy: An Overview......Page 215
17 Tachykinin Receptor Antagonists: Silencing Neuropeptides with a Role in the Disturbed Gut......Page 224
18 Serotonin Receptor Modulators......Page 240
19 Emerging Transmitters......Page 260
Index......Page 267
