The two volumes on Parkinson's disease in the Handbook of Clinical Neurology (Series Editors: Michael J. Aminoff, Department of Neurology, University of California, San Francisco, USA; Fran?§ois Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) cover a group of disorders that constitute the commonest of neurodegenerative diseases and one that is assuming ever greater importance with the ageing of the population in developed countries. The coverage reflects the dramatic advances in understanding of the biochemical background of parkinsonism and the resulting developments in the pharmacological management of the disease. These volumes give a comprehensive account of the subject for both clinical neurologists and those researching in the neurosciences.Part I covers the scientific background, general aspects of Parkinson's disease, clinical aspects and etiology. Part II covers the medical and surgical treatment of Parkinson's disease, complications of therapy and the other parkinsonian syndromes.
Author(s): William C. Koller MD PhD, Eldad Melamed MD
Edition: 1
Year: 2007
Language: English
Pages: 656
Cover......Page 1
Obituary......Page 2
Foreword......Page 3
Preface......Page 4
List of contributors......Page 5
Contents......Page 11
01 Anatomy and physiology of the basal ganglia- relevance to Parkinson's disease and related disorders.pdf......Page 14
02 Functional neurochemistry of the basal ganglia.pdf......Page 31
03 Neurophysiology of basal ganglia diseases.pdf......Page 79
04 Dopamine receptor pharmacology.pdf......Page 88
05 History of Parkinson's disease.pdf......Page 117
06 Epidemiology of Parkinson's disease.pdf......Page 138
07 Neurochemistry of Parkinson's disease.pdf......Page 161
08 The neuropathology of parkinsonism.pdf......Page 213
09 Genetic aspects of Parkinson's disease.pdf......Page 224
10 Imaging Parkinson's disease.pdf......Page 252
11 Parkinson's disease- animal models.pdf......Page 271
12 Scales to measure parkinsonism.pdf......Page 294
13 Motor symptoms in Parkinson's disease.pdf......Page 332
14 Autonomic dysfunction in Parkinson's disease.pdf......Page 346
15 Sleep in Parkinson syndromes.pdf......Page 367
16 Sensory symptoms in Parkinson's disease.pdf......Page 379
17 Speech disorders in Parkinson's disease and the effects of pharmacological, surgical and speech treatment with emphasis on Lee Silverman voice treatment.pdf......Page 387
18 Clinical features, pathophysiology and treatment of dementia associated with Parkinson's disease.pdf......Page 402
19 Disorders of mood and affect in Parkinson's disease.pdf......Page 421
20 Neurobehavioral disorders in Parkinson's disease.pdf......Page 434
21 Early detection of Parkinson's disease.pdf......Page 455
22 Mitochondria in the etiology of Parkinson's disease.pdf......Page 476
23 Iron as a trigger of neurodegeneration in Parkinson's disease.pdf......Page 488
24 Oxidative stress and Parkinson's disease.pdf......Page 501
25 Neurotrophic factors and Parkinson's disease.pdf......Page 515
26 Neuroinflammation and Parkinson's disease.pdf......Page 528
27 Excitotoxicity.pdf......Page 545
28 Protein-handling dysfunction in Parkinson's disease.pdf......Page 562
29 Programmed cell death in Parkinson's disease.pdf......Page 582
Subject Index......Page 597
