Since the first M. D. Anderson Solid Tumor Oncology Series volume on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. We have seen the development of the first mouse models that accurately recapitulate features of the human disease. Several landmark clinical trials in both resectable and metastatic pancreatic cancer have been completed, raising new questions about the standard of care in this disease.
Finally, the era of targeted biologic therapies has engendered new excitement about the prospects of more rapid progress in understanding and successfully treating this dreadful disease. Therefore, it is an appropriate time to review these important advances and outline areas of controversy and question in pancreatic cancer biology and treatment.
Author(s): N. Volkan Adsay MD, Duangpen Thirabanjasak MD, Deniz Altinel MD (auth.), Andrew M. Lowy, Steven D. Leach, Philip A. Philip (eds.)
Series: M. D. Anderson Solid Tumor Oncology Series
Edition: 1
Publisher: Springer US
Year: 2008
Language: English
Pages: 744
Tags: Oncology; Surgical Oncology
Front Matter....Pages i-xviii
Spectrum of Human Pancreatic Neoplasia....Pages 3-26
Molecular Genetics of Pancreatic Cancer....Pages 27-39
Pancreatic Intraepithelial Neoplasia....Pages 41-51
Pathology and Molecular Biology of Intraductal Papillary Mucinous Neoplasms....Pages 53-64
Familial Pancreatic Cancer....Pages 65-79
Hereditary Pancreatitis and Pancreatic Cancer....Pages 81-96
Pancreatic Progenitor Cells in Injury and Regeneration....Pages 99-116
Development of the Endocrine and Exocrine Pancreas....Pages 117-135
Models of Pancreatic Cancer: Understanding Disease Progression....Pages 137-158
From Inception to Invasion: Modeling Pathways to Pancreatic Cancer....Pages 159-179
Molecular Signaling Pathways in Pancreatic Cancer....Pages 181-228
Pancreatic Cancer Genomics, Epigenomics, and Proteomics....Pages 229-252
Imaging of Pancreatic Adenocarcinoma....Pages 255-270
The Role of PET Scanning in Pancreatic Cancer....Pages 271-283
Endoscopic Ultrasound Staging....Pages 285-294
Laparoscopic Staging....Pages 295-310
Pancreaticoduodenectomy: Past and Present....Pages 313-327
Total Pancreatectomy for Treatment of Pancreatic Adenocarcinoma....Pages 329-339
Distal Pancreatectomy....Pages 341-350
Vascular Resection for Pancreatic Cancer....Pages 351-363
Complications of Pancreaticoduodenectomy....Pages 365-384
Controversies in the Surgical Management of Pancreatic Cancer....Pages 385-400
Laparoscopic Pancreatic Resections....Pages 401-417
Surgical Management of IPMN....Pages 419-432
Cancer Pain and Symptom Management: Drug Therapy....Pages 435-447
Supportive Care: Cachexia, Anorexia Syndrome....Pages 449-462
Endoscopic Palliation....Pages 463-478
State of the Art in Radiation Therapy for Pancreas Cancer....Pages 481-496
The Evolution of Chemoradiation Strategies for Locally Advanced Pancreatic Cancer....Pages 497-510
Optimum Cytotoxic Therapy for Advanced Pancreatic Cancer....Pages 511-533
Adjuvant Chemoradiation for Pancreatic Cancer: Past, Present and Future....Pages 535-547
Neoadjuvant Treatment for Resectable and Locally Advanced Pancreatic Cancer....Pages 549-562
An Overview of Clinical Trials of Targeted Therapies in Pancreatic Cancer....Pages 565-575
Utility of Animal Models in Pancreatic Cancer Research....Pages 577-599
K-ras Inhibitors and Pancreatic Cancer....Pages 601-607
HER Family of Receptors as Treatment Targets in Pancreatic Cancer....Pages 609-634
GSK-3β Inhibition in Pancreatic Cancer....Pages 635-646
Inactivation of NF-κB....Pages 647-664
Novel Targets for the Treatment of Pancreatic Cancer I: Insulin-like Growth Factor Receptor....Pages 665-676
Novel Targets for the Treatment of Pancreatic Cancer II: The Hedgehog Signaling Pathway....Pages 677-682
Development of Vaccine Therapy for Pancreas Cancer....Pages 683-704
Novel Approaches in Chemoradiation for Localized Pancreas Cancer....Pages 705-712
Incorporation of Genomics and Proteomics in Drug and Biomarker Development....Pages 713-721
Pitfalls in Clinical Trials and Future Directions....Pages 723-731
Back Matter....Pages 733-744
