Based on the 2009 proceedings of the 37th annual ISOTT conference, this volume covers all aspects of oxygen delivery to tissue, everything from near infrared spectroscopy, tumor biology, angiogenesis and mitochondrial metabolism to systems modeling, gas transport, hypoxic adaptation and exercise physiology. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biological bases for pathology related to tissue oxygenation. This multidisciplinary volume includes contributions from scientists, engineers, clinicians and mathematicians and is aimed and students and experts from a range of research fields.
Author(s): Joseph C. LaManna Ph.D. (auth.), Joseph C. LaManna, Michelle A. Puchowicz, Kui Xu, David K Harrison, Duane F. Bruley (eds.)
Series: Advances in Experimental Medicine and Biology 701
Edition: 1
Publisher: Springer US
Year: 2011
Language: English
Pages: 374
Tags: Human Physiology; Immunology; Pneumology/Respiratory System
Front Matter....Pages i-xxx
Front Matter....Pages 1-1
The Western Reserve, Edward Morley, and Oxygen....Pages 3-8
Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during Hypercapnoea....Pages 9-14
Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements Using NIRS during a Valsalva Manoeuvre....Pages 15-20
Speech Therapy Changes Blood Circulation and Oxygenation in the Brain and Muscle....Pages 21-25
Front Matter....Pages 27-27
Evaluation of Lithium Naphthalocyanine (LiNc) Microcrystals for Biological EPR Oximetry....Pages 29-36
Challenges to Intestinal pO 2 Measurement Using EPR....Pages 37-44
Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis....Pages 45-51
Measuring Oxygen in Living Tissue: Intravascular, Interstitial, and “Tissue” Oxygen Measurements....Pages 53-59
Cerebral Oxygenation of the Cortex and Striatum Following Normobaric Hyperoxia and Mild Hypoxia in Rats by EPR Oximetry Using Multi-Probe Implantable Resonators....Pages 61-67
31 P-MRS Studies of Melanoma Xenografts with Different Metastatic Potential....Pages 69-73
Modulation of Tumor Hypoxia by Topical Formulations with Vasodilators for Enhancing Therapy....Pages 75-82
Front Matter....Pages 83-83
MP4, a Vasodilatory PEGylated Hemoglobin....Pages 85-90
Zymogen Protein C to Prevent Clotting without Bleeding during Invasive Medical Procedures....Pages 91-97
Front Matter....Pages 99-99
Oxygenation Status of Urogenital Tumors....Pages 101-106
Tumor pO 2 as a Surrogate Marker to Identify Therapeutic Window during Metronomic Chemotherapy of 9L Gliomas....Pages 107-113
Hypoxia-Induced Extracellular Acidosis Increases p-Glycoprotein Activity and Chemoresistance in Tumors in Vivo via p38 Signaling Pathway....Pages 115-122
Evidence against a Major Role for TKTL-1 in Hypoxic and Normoxic Cancer Cells....Pages 123-128
NMR Metabolic and Physiological Markers of Therapeutic Response....Pages 129-135
Characterizing Breast Cancer Mouse Xenografts with T 1ρ -MRI....Pages 137-142
Effect of AEM Energy Applicator Configuration on Magnetic Nanoparticle Mediated Hyperthermia for Breast Cancer....Pages 143-148
Front Matter....Pages 99-99
Highly Specific, NIR Fluorescent Contrast Agent with Emission Controlled by Gold Nanoparticle....Pages 149-154
Front Matter....Pages 155-155
Oral Pioglitazone Reduces Infarction Volume and Improves Neurologic Function Following MCAO in Rats....Pages 157-162
Front Matter....Pages 163-163
Chronic Mild Hypoxia Ameliorates Chronic Inflammatory Activity in Myelin Oligodendrocyte Glycoprotein (MOG) Peptide Induced Experimental Autoimmune Encephalomyelitis (EAE)....Pages 165-173
Effect of Oxygenation on Stem-Cell Therapy for Myocardial Infarction....Pages 175-181
Front Matter....Pages 183-183
Regulation of Cytosolic and Mitochondrial Oxidation via Malate-Aspartate Shuttle: An Observation Using Dynamic 13 C NMR Spectroscopy....Pages 185-192
In Vivo Assessment of Oxygen Consumption via Deuterium Magnetic Resonance....Pages 193-199
Elevated Mitochondrial DNA Copy Number and POL- γ Expression but Decreased Expression of TFAM in Murine Intestine Following Therapeutic Dose Irradiation....Pages 201-206
Heterogeneity of Mitochondrial Redox State in Premalignant Pancreas in a PTEN Null Transgenic Mouse Model....Pages 207-213
Potential Application of 17 O MRI to Human Ischemic Stroke....Pages 215-222
Front Matter....Pages 223-223
Fetal Cerebral Oxygenation: The Homeostatic Role of Vascular Adaptations to Hypoxic Stress....Pages 225-232
Impaired Cerebral Autoregulation Using Near-Infrared Spectroscopy and Its Relation to Clinical Outcomes in Premature Infants....Pages 233-239
Front Matter....Pages 241-241
Variable ATP Yields and Uncoupling of Oxygen Consumption in Human Brain....Pages 243-248
Interpretation of NMR Spectroscopy Human Brain Data with a Multi-Compartment Computational Model of Cerebral Metabolism....Pages 249-254
Regional Brain Blood Flow in Mouse: Quantitative Measurement Using a Single-Pass Radio-Tracer Method and a Mathematical Algorithm....Pages 255-260
Front Matter....Pages 261-261
Wound Healing in Diabetes: Hemorheological and Microcirculatory Aspects....Pages 263-269
Modeling O 2 -Dependent Effects of Nitrite Reductase Activity in Blood and Tissue on Coupled NO and O 2 Transport around Arterioles....Pages 271-276
Skin SO 2 Measurement Using Visible Lightguide Spectrophotometry in a Black Population: A Feasibility Study....Pages 277-282
Antioxidant Properties of Quercetin....Pages 283-289
Antioxidant Properties of Select Radiation Mitigators Based on Semicarbazone and Pyrazole Derivatives of Curcumin....Pages 291-297
Front Matter....Pages 299-299
Impact of Intracellular Diffusion of Oxygen in Hypoxic Sensing....Pages 301-306
Front Matter....Pages 299-299
Micropores in the Vitteline Layer of the Eggs of the Dragonfly Oligoaeshna pryeri : A Preliminary Observation from the Viewpoint of Oxygen Uptake....Pages 307-310
Front Matter....Pages 311-311
A Heat-Shock Protein Co-Inducer Treatment Improves Behavioral Performance in Rats Exposed to Hypoxia....Pages 313-318
Chronic Intermittent Hypoxia-Induced Augmented Cardiorespiratory Outflow Mediated by Vasopressin-V 1A Receptor Signaling in the Medulla....Pages 319-325
Effect of Inspiration of 12%O 2 (Balance N 2 ) on Cardiac Output, Respiration, Oxygen Saturation, and Oxygen Delivery....Pages 327-332
Front Matter....Pages 333-333
Sufficient Oxygen Can Be Transported to Resting Skeletal Muscle via Arterialization of the Vein: Theoretical Considerations in a Rat Model....Pages 335-339
Skeletal Muscle Perfusion and Oxygenation Assessed by Dynamic NMR Imaging and Spectroscopy....Pages 341-346
Hemoglobin and Myoglobin Contributions to Skeletal Muscle Oxygenation in Response to Exercise....Pages 347-352
Estimation of Muscle Fatigue Using Surface Electromyography and Near-Infrared Spectroscopy....Pages 353-359
Erratum to: Variable ATP Yields and Uncoupling of Oxygen Consumption in Human Brain....Pages E1-E3
Erratum....Pages E5-E6
Back Matter....Pages 361-368
