Oxygen Transport to Tissue XLII

Preface
Contents
Part I: Oxygen Metabolism and Health Monitoring
1: Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain
1.1 Introduction
1.2 Methods
1.3 Results
1.4 Discussion
References
2: Event-Related NIRS and EEG Analysis for Mental Stress Monitoring
2.1 Introduction
2.2 Methods
2.3 Results
2.4 Discussion
References
3: Simulation Study of Breast Cancer Lipid Changes Affecting Membrane Oxygen Permeability: Effects of Chain Length and Cholesterol
3.1 Introduction
3.2 Methods
3.3 Results and Discussion
3.4 Conclusions
References
4: Updated Evaluation of Cholesterol’s Influence on Membrane Oxygen Permeability
4.1 Introduction
4.2 Methods
4.3 Results and Discussion
4.4 Conclusions
References
5: Systems Biology Model of Cerebral Oxygen Delivery and Metabolism During Therapeutic Hypothermia: Application to the Piglet Model
5.1 Introduction
5.2 Methods
5.3 Result
5.4 Discussion
References
6: Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model
6.1 Introduction
6.2 Methods
6.2.1 Animal Preparation
6.2.2 Statistical Analysis
6.3 Results
6.4 Discussion
6.5 Conclusion
References
7: Two Consecutive Invasive Surgeries Utilizing Zymogen Protein C (ZPC) That Enhanced Patient Safety and Reduced Costs
7.1 Introduction
7.2 Case Presentation
7.3 Discussion
References
8: Scanning Tissue Oxygen Needle Probe
8.1 Introduction
8.2 Sensor Design
8.2.1 Oxygen Sensing by Phosphorescence
8.2.2 Needle Probe Optical Scanner Design
8.3 Simulation Study
8.4 In Vivo Pilot Study
8.5 Conclusions
References
9: Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation of the Brain
9.1 Introduction
9.2 Methods
9.3 Results
9.3.1 The Effects of tPBM on the Level of Aβ in the Mouse Brain with AD
9.3.2 Mechanisms of Therapeutic Effects of tPBM in Mice with AD
9.4 Conclusions
References
10: Near-Infrared Spectroscopy Might Help Prevent Onset of Cerebral Hyperperfusion Syndrome
10.1 Introduction
10.2 Methods
10.2.1 Patient Preparation
10.2.2 Statistical Analysis
10.3 Results
10.4 Discussion
10.5 Conclusion
References
Part II: Oxygen Measurement and Modeling
11: Online Assessment of Hemodynamics in the Suctioned Volume of Biological Tissue by an Embedded Near-Infrared Spectroscopy Sensor
11.1 Introduction
11.2 Materials and Methods
11.3 Results
11.4 Discussion
References
12: Skeletal Muscle Deoxygenation and Its Relationship to Aerobic Capacity During Early and Late Stages of Aging
12.1 Introduction
12.2 Methods
12.2.1 Subjects
12.2.2 Experimental Design
12.2.3 Statistical Analysis
12.3 Results
12.4 Discussion
References
13: Near-Infrared Spectroscopy (NIRS) of Muscle HbO2 and MbO2 Desaturation During Exercise
13.1 Introduction
13.2 Material and Methods
13.3 Results (Figs. 13.1, 13.2, and 13.3)
13.4 Discussion and Conclusions
References
14: Relationship Between Corticosteroid Dose and Muscle Oxygen Consumption in Recipients of Hematopoietic Stem-Cell Transplantation
14.1 Introduction
14.2 Methods
14.2.1 Participants
14.2.2 Experimental Procedure
14.2.3 NIRS Measurements
14.2.4 Statistical Analysis
14.3 Results
14.4 Discussion
References
15: Relationship Between the Borg Scale Rating of Perceived Exertion and Leg-Muscle Deoxygenation During Incremental Exercise in Healthy Adults
15.1 Introduction
15.2 Methods
15.2.1 Participants
15.2.2 Experimental Procedure
15.2.3 NIRS Measurements
15.2.4 Statistical Analysis
15.3 Results
15.4 Discussion
References
16: Effects of Exercise Training on Cardiac and Skeletal Muscle Functions in Patients with Chronic Heart Failure
16.1 Introduction
16.2 Methods
16.2.1 Subjects
16.2.2 Exercise Testing
16.2.3 CO Measurement
16.2.4 Skeletal Muscle Oxygenation Measurement
16.2.5 Statistical Analysis
16.3 Results
16.3.1 Comparison Between CHFpre and CON
16.3.2 Comparison Between CHFpre and CHFpost
16.4 Discussion
16.5 Conclusion
References
17: Reduced Scattering Coefficient During Incremental Exercise Is Constant Without Being Affected by Changes in Muscle Oxygenation or Hemodynamics
17.1 Introduction
17.2 Methods
17.3 Results
17.4 Discussion and Conclusions
References
18: Changes in the Laterality of Oxygenation in the Prefrontal Cortex and Premotor Area During a 20-Min Moderate-Intensity Cycling Exercise
18.1 Introduction
18.2 Methods
18.2.1 Participants
18.2.2 Experimental Procedure
18.2.3 NIRS Measurements
18.2.4 Blood Pressure and SBF Measurements
18.2.5 Statistical Analysis
18.3 Results
18.4 Discussion
References
19: Relationship Between Decrease of Oxygenation During Incremental Exercise and Partial Pressure End-Tidal Carbon Dioxide: Near-Infrared Spectroscopy Vector Analysis
19.1 Introduction
19.2 Methods
19.2.1 Participants and Procedures
19.2.2 Cortical Oxygenation
19.2.3 PETCO2 and SBF
19.2.4 Statistical Analysis
19.3 Results
19.4 Discussion
References
20: Cerebral Oxygenation Dynamics During Incremental Exercise: Comparison of Arm Cranking and Leg Cycling
20.1 Introduction
20.2 Methods
20.3 Results
20.4 Discussion
References
21: Localization of Deep Ischemia and Hemorrhage in Preterm Infants’ Head with Near-Infrared Optical Tomography: A Numerical Case Study
21.1 Introduction
21.2 Methods
21.2.1 Forward Model
21.2.2 Image Reconstruction
21.2.3 Evaluation Parameters
21.3 Results and Discussion
21.4 Conclusion and Outlook
References
22: Discerning Membrane Steady-State Oxygen Flux by Monte Carlo Markov Chain Modeling
22.1 Introduction
22.2 Methods
22.3 Results and Discussion
22.4 Conclusions and Expansion of the Model
References
Part III: Tumor Oxygenation and Modeling
23: The Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis
23.1 Introduction
23.2 Methods
23.2.1 Cell Line
23.2.2 Experimental Settings
23.3 Results
23.4 Conclusion
References
24: Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells
24.1 Introduction
24.2 Methods
24.2.1 Cell Line
24.2.2 Experimental Settings
24.3 Results
24.4 Conclusion
References
25: Impact of Acidosis-Regulated MicroRNAs on the Expression of Their Target Genes in Experimental Tumors In Vivo
25.1 Introduction
25.2 Methods
25.2.1 Cell Culture and In Vivo Tumor Models
25.2.2 Experimental Settings
25.3 Results
25.4 Conclusion
References
26: An Observation on Enhanced Extracellular Acidification and Lactate Production Induced by Inhibition of Lactate Dehydrogenase A
26.1 Introduction
26.2 Methods
26.3 Results
26.4 Discussion and Conclusion
References
27: The Warburg Effect: Historical Dogma Versus Current Rationale
27.1 Introduction
27.2 The Warburg Effect: Essential Part of Metabolic Reprogramming and Favoring Biosynthesis Pathways
27.2.1 Major Biochemical Steps of Aerobic Glycolysis
27.2.2 The Warburg Effect and Energy Homeostasis
27.2.3 The Warburg Effect Ensures Redox Homeostasis and Reduces ROS Production
27.3 Regulatory Network of the Warburg Effect
27.4 Warburg Effect: The Role of Lactate Accumulation and Extracellular Acidosis
27.5 Conclusions
References
28: The Acidic Tumor Microenvironment Affects Epithelial-Mesenchymal Transition Markers as Well as Adhesion of NCI-H358 Lung Cancer Cells
28.1 Introduction
28.2 Methods
28.2.1 Cell Line
28.2.2 Experimental Settings
28.3 Results
28.4 Conclusions
References
29: Assessment of the Probability of Tumour Control for Prescribed Doses Based on Imaging of Oxygen Partial Pressure
29.1 Introduction
29.2 Methods
29.3 Results and Discussion
29.4 Conclusions
References
30: On the Feasibility of Skin Water Content Imaging Adjuvant to Tissue Oximetry
30.1 Introduction
30.2 Methods
30.2.1 Imaging
30.2.2 Processing
30.3 Results
30.4 Conclusions
References
31: Mechanisms of Sound-Induced Opening of the Blood-Brain Barrier
31.1 Introduction
31.2 Methods
31.3 Results
31.3.1 Blood-Brain Barrier Opening to High-Molecular-Weight Molecules
31.3.2 Systemic and Metabolic Responses Induced by Loud Sound
31.3.3 Sound-Induced Changes in TJ Machinery
31.3.4 Sound-Induced BBB Opening Is Associated with Activation of Lymphatic Clearance of Molecules Crossing the Opened BBB
31.4 Conclusions
References
32: Multimodal Measurements of Brain Tissue Metabolism and Perfusion in a Neonatal Model of Hypoxic-Ischaemic Injury
32.1 Introduction
32.2 Methods
32.2.1 Animal Model of HI
32.2.2 Measurements of Cerebral Metabolism
32.2.3 Data Analysis
32.3 Results
32.4 Discussion
References
33: Cerebral Spreading Depression Transient Disruption of Cross-Frequency Coupling in the Rat Brain: Preliminary Observations
33.1 Introduction
33.2 Material and Methods
33.2.1 Animal Model
33.2.2 Recording System and Electrodes
33.2.3 Data Analysis
33.3 Results
33.4 Discussion and Conclusions
References
34: Long-Term Blue Light Exposure Changes Frontal and Occipital Cerebral Hemodynamics: Not All Subjects React the Same
34.1 Introduction
34.2 Material and Methods
34.3 Results
34.4 Discussion and Conclusions
References
35: Changes in Prefrontal Cortex Asymmetry Due to Standing Load in Stroke Patients Measured by NIRS
35.1 Introduction
35.2 Methods
35.2.1 Subjects
35.2.2 NIRS Measurements
35.2.3 Data Analysis
35.3 Results
35.4 Discussion
35.5 Conclusions
References
36: Parasympathetic Nervous Activity Associated with Discoordination Between Physical Acceleration and Heart Rate Variability in Patients with Sleep Apnea
36.1 Introduction
36.2 Methods
36.2.1 Subjects
36.2.2 Protocols
36.2.3 Oxygen Desaturation Index
36.2.4 Questionnaire
36.2.5 Physical Acceleration
36.2.6 Analysis
36.2.7 Statistics and Ethics
36.3 Results
36.4 Discussion
References
37: The Changes in Brain Oxygenation During Transcranial Alternating Current Stimulation as Consequences of Traumatic Brain Injury: A Near-Infrared Spectroscopy Study
37.1 Introduction
37.2 Methods
37.2.1 tACS
37.2.2 Cerebral Oximetry
37.2.3 Statistical Analysis
37.3 Results
37.4 Discussion
37.5 Conclusion
References
38: Error Evaluation for Automated Diameter Measurements of Cerebral Capillaries Captured with Two-Photon Laser Scanning Fluorescence Microscopy
38.1 Introduction
38.2 Methods
38.3 Results
38.4 Discussion
References
39: Potential Biomarker for Triple-Negative Breast Cancer Invasiveness by Optical Redox Imaging
39.1 Introduction
39.2 Materials and Methods
39.3 Results
39.4 Discussion and Conclusions
References
40: Optical Redox Imaging Differentiates Triple-Negative Breast Cancer Subtypes
40.1 Introduction
40.2 Methods
40.2.1 Cell Culture and Perturbation Drugs
40.2.2 Live Cell Optical Redox Imaging and Analysis
40.3 Results and Discussion
40.3.1 ORI Differentiates TNBC Cell Lines
40.3.2 ORI Detects Metabolic Changes in TNBC Cell Lines
40.3.3 TNBC Cell Lines Have Differential FAD and Redox Ratio Plasticity
References
41: Oxygen-Sensing Paramagnetic Probes for Clinical Oximetry
41.1 Introduction
41.2 EPR Oxygen Sensors
41.2.1 SPOTChip for Topical Oximetry
41.2.2 MicroChip for Superficial (1–5-mm Depth) Tissue Oximetry
41.2.3 OxyChip for Shallow-Depth (<10 mm) Tissue Oximetry
41.2.4 OxyChip-EL for Deep-Tissue (>10 mm) Oximetry
41.3 Oxygen Sensor Applications
41.4 Conclusion
References
42: Evaluation of the Quality of Chest Compression with Oxyhemoglobin Level by Near-Infrared Spectroscopy in a Rat Asphyxia Cardiac Arrest Model
42.1 Introduction
42.2 Methods
42.2.1 Animal Preparation
42.2.2 Cardiopulmonary Resuscitation
42.2.3 Statistical Analysis
42.3 Results
42.4 Discussion
42.5 Conclusion
References
43: Altered Behavioral Performance in the Neuron-Specific HIF-1- and HIF-2-Deficient Mice Following Chronic Hypoxic Exposure
43.1 Introduction
43.2 Methods
43.2.1 Animals and Hypoxic Exposure
43.2.2 Behavioral Performance
43.2.3 Statistical Analysis
43.3 Results
43.4 Discussion
References
44: Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model
44.1 Introduction
44.2 Methods
44.2.1 Animal Preparation
44.2.2 Statistical Analysis
44.3 Results
44.4 Discussion
44.5 Conclusion
References
45: Addition of Drag-Reducing Polymers to Colloid Resuscitation Fluid Enhances Cerebral Microcirculation and Tissue Oxygenation After Traumatic Brain Injury Complicated by Hemorrhagic Shock
45.1 Introduction
45.2 Methods
45.3 Results
45.4 Discussion
45.5 Conclusion
References
46: Effects of 20-Minute Intensive Exercise on Subjects with Different Working Memory Bases
46.1 Introduction
46.2 Methods
46.3 Results
46.4 Discussion
46.5 Conclusions
References
47: Supine Cycling Exercise Enhances Cerebral Oxygenation of Motor-Related Areas in Healthy Male Volunteers
47.1 Introduction
47.2 Methods
47.3 Results
47.4 Discussion
References
48: What Is the Meaning of an Oxygen Measurement?
48.1 Introduction
48.2 Analysis of the Ability of Clinically Available Techniques to Measure Absolute Levels of O2 and/or Resolve Heterogeneity of O2 Distributions in Tissues
48.2.1 Direct Measures of O2 in Targeted Tissues
48.2.2 Direct Measures of O2 in the Vascular System
48.2.3 Indirect Measures of Tissue Oxygen
48.3 Discussion
48.4 Conclusions
References
Part IV: Brain Oxygenation and Function
49: Assessment of Cerebral Blood Oxygenation by Near-Infrared Spectroscopy before and after Resuscitation in a Rat Asphyxia Cardiac Arrest Model
49.1 Introduction
49.2 Methods
49.2.1 Animal Surgical Procedure
49.2.2 Statistical Analysis
49.3 Results
49.4 Discussion
49.5 Conclusions
References
50: Effect of 3-Day and 21-Day Hypoxic Preconditioning on Recovery Following Cerebral Ischemia in Rats
50.1 Introduction
50.2 Methods
50.2.1 Animals and Hypoxic Preconditioning
50.2.2 Permanent MCAO and Infarct Volume Analysis
50.2.3 Western Blot Analysis
50.2.4 Statistical Analysis
50.3 Results
50.4 Discussion
References
51: Time Series Tracking of Cerebral Microvascular Adaptation to Hypoxia and Hyperoxia Imaged with Repeated In Vivo Two-Photon Microscopy
51.1 Introduction
51.2 Methods
51.3 Results
51.4 Discussion
References
52: Environmental Enrichment Improved Cognitive Performance in Mice under Normoxia and Hypoxia
52.1 Introduction
52.2 Methods
52.2.1 Animals, Environmental Enrichment, and Hypoxic Exposure
52.2.2 Measurement of Cognitive Function
52.2.3 Statistical Analysis
52.3 Results
52.4 Discussion
References
53: Effect of Prolonged Pressure on Hemodynamics of Sacral Tissues Assessed by Diffuse Optical Imaging: A Pilot Study
53.1 Introduction
53.2 Methods
53.3 Results
53.4 Discussion
53.5 Conclusion
References
54: In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage
54.1 Introduction
54.2 Methods
54.3 Results and Discussion
54.3.1 No-Prior Reconstruction
54.3.2 Region-Based Reconstruction
54.4 Conclusions
References
55: Online Noninvasive Assessment of Human Brain Death by Near-Infrared Spectroscopy with Protocol of O2 Inspiration
55.1 Introduction
55.2 Methods
55.3 Results
55.4 Conclusions
References
56: Not Removing the Glossy White Cover from Adhesive INVOS Neonatal Sensors Affects the Oxygenation Measurement
56.1 Introduction
56.2 Methods
56.3 Results
56.4 Discussion
References
57: Probe Design Optimization for Time-Domain NIROT “Pioneer” System for Imaging the Oxygenation of the Preterm Brain
57.1 Introduction
57.2 Method
57.3 Results
57.4 Discussion
57.5 Conclusion
References
Part V: Interstitium, Lymphatics and Blood
58: Effect of Blood Flow on Hemoglobin and Myoglobin Oxygenation in Contracting Muscle Using Near-Infrared Spectroscopy
58.1 Introduction
58.2 Methods
58.3 Results
58.4 Discussion
References
59: Magnetoresistance Properties of Red Blood Cells in Plasma Combined with Several Magnetic Beads Passing Two Cu Electrodes
59.1 Introduction
59.2 Materials and Methods
59.3 Experimental Results and Discussion
59.4 Conclusions
References
60: Measurement of Tissue Oxygen as a Novel Approach to Optimizing Red Blood Cell Quality Assessment
60.1 Introduction
60.2 Overview of Methods to Measure Oxygen in Tissues to Assess the Efficacy of RBC Preparations
60.3 EPR Measurements of Impact of RBC Preparations on Oxygen in Tissues: A Rat Blood Loss/Transfusion Experiment
60.4 Discussion and Conclusions
References
61: Gene Expression of Prox-1 and Hif-1a in Primo Vessels Inside Lymph Vessels of the Rabbit
61.1 Introduction
61.2 Materials and Methods
61.3 Differentially Expressed Genes (DEGs) of Prox-1 and Hifl-a in PV
61.4 Prox-1 and Hif-1a Gene Expression Analysis of PV in LV of LPS- and AES-Treated Rabbits
61.5 Conclusions
References
62: On the Feasibility of Pulse Wave Velocity Imaging for Remote Assessment of Physiological Functions
62.1 Introduction
62.2 Methods
62.2.1 Data Acquisition
62.2.2 Image Processing
62.3 Results and Discussion
62.4 Conclusions
References
Author Index
Subject Index