Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics.
Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium.
This second edition includes exciting new advances in ovarian cancer detection and treatment and provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A more detailed understanding of these processes may ultimately translate into the development of novel approaches for the detection and control of ovarian cancer.
"Ovarian Cancer prevention, detection and treatment remain a significant health care challenge. In this text thought leaders in the field address the critical biologic and clinical issues relevant to the disease. A comprehensive spectrum of topics is covered providing up to date information on scientific discoveries and management considerations."
Steven T. Rosen, M.D.
Author(s): Anna Hoekstra, Gustavo C. Rodriguez (auth.), M. Sharon Stack, David A. Fishman (eds.)
Series: Cancer Treatment and Research 149
Edition: 2
Publisher: Springer US
Year: 2010
Language: English
Pages: 408
Tags: Oncology; Gynecology; Cancer Research; Human Genetics
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Chemoprevention of Ovarian Cancer....Pages 3-34
Staging and Surgical Treatment....Pages 35-61
Novel Therapeutic Targets....Pages 63-84
Biomarker Targets and Novel Therapeutics....Pages 85-105
Front Matter....Pages 107-107
Tumor Suppressor Genes....Pages 109-129
Epigenetics and Ovarian Cancer....Pages 131-146
Aberrant Epithelial Differentiation in Ovarian Cancer....Pages 147-163
The Human Kallikrein Gene Family: New Biomarkers for Ovarian Cancer....Pages 165-187
Soluble Epidermal Growth Factor Receptor: A Biomarker of Epithelial Ovarian Cancer....Pages 189-202
Activated Epidermal Growth Factor Receptor in Ovarian Cancer....Pages 203-226
Front Matter....Pages 227-227
Ras-Superfamily GTP-ases in Ovarian Cancer....Pages 229-240
Lipid Generation and Signaling in Ovarian Cancer....Pages 241-267
Lysophosphatidic Acid and Invasion....Pages 269-296
Cell Adhesion in Ovarian Cancer....Pages 297-318
Microenvironmental Regulation of Ovarian Cancer Metastasis....Pages 319-334
Organotypic Models of Metastasis: A Three-dimensional Culture Mimicking the Human Peritoneum and Omentum for the Study of the Early Steps of Ovarian Cancer Metastasis....Pages 335-351
Animal Models of Ovarian Cancer....Pages 353-391
Back Matter....Pages 393-408
