Osteoclasts: Cell Biology, Functions and Related Diseases (Cell Biology Research Progress)

OSTEOCLASTS CELL BIOLOGY, FUNCTIONS AND RELATED DISEASES......Page 3
OSTEOCLASTS CELL BIOLOGY, FUNCTIONS AND RELATED DISEASES......Page 5
Library of Congress Cataloging-in-Publication Data......Page 6
CONTENTS......Page 7
PREFACE......Page 9
ABSTRACT......Page 13
INTRODUCTION......Page 14
1. BIOGENESIS OF MICRORNA AND EXTRACELLULAR VESICLES......Page 15
miR-21......Page 17
miR-31......Page 19
miR-124......Page 20
miR-146a......Page 21
miR-223......Page 22
Extracellular Vesicles......Page 23
ACKNOWLEDGMENTS......Page 24
REFERENCES......Page 25
ABSTRACT......Page 31
INTRODUCTION......Page 32
Cobra Venom Factor Treatment and Complement Activity Assay......Page 35
Determination of IFN-......Page 36
Histotopathological Examination......Page 37
Statistics......Page 38
Osteoclast Differentiation of BM Cells and Osteoblast Formation of Calvarial Cells......Page 39
Complement Depletion Reduced TRAP Positive Cells in the Joint......Page 42
Influence of CVF-Treatment on RANKL, TRAIL and DR5 Expression by BM Cells......Page 43
DISCUSSION......Page 45
REFERENCES......Page 48
ABSTRACT......Page 53
INTRODUCTION......Page 54
REFERENCES......Page 58
ABSTRACT......Page 63
I. INTRODUCTION......Page 64
II. HUMAN BONE DISEASES CAUSED BY OSTEOCLAST DYSREGULATION......Page 65
1. Ps to PsA Transition and Medication Response......Page 67
B. Targeted Drug Delivery to Promote Bone Healing......Page 69
A. OC-STAMP vs. DC-STAMP......Page 70
B. Is DC-STAMP a GPCR-Like Protein That Is Involved in the Apoptosis Regulation?......Page 71
C. Bone Marrow Is the Major Reservoir of DC-STAMP+ OCPs......Page 73
E. Proteins that Interact with DC-STAMP and Regulate DC-STAMP Expression......Page 75
E.1. DC-STAMP-Interacting Proteins......Page 76
2.2. Pin1 [7]......Page 77
2.4. MiR-7b [63]......Page 78
V. BIOLOGICAL PATHWAYS LIKELY TO BE MEDIATED BY DC-STAMP......Page 79
A. Cytoskeleton Rearrangement......Page 81
C. Selection of Fusion Partner......Page 84
D. RANKL-ITAM-ITIM Signaling......Page 85
E. OB::OC Coupling......Page 86
G. Tooth Development: Eruption and Remodeling......Page 87
CONCLUDING REMARKS AND FUTURE DIRECTIONS......Page 88
REFERENCES......Page 90
INDEX......Page 101