This book introduces and discusses the latest in biomedical research--Pharmaceutical Nanotechnology applied at the sub-cellular level.
Author(s): Volkmar Weissig, Gerard G. D'Souza
Edition: 1
Publisher: Wiley
Year: 2010
Language: English
Pages: 638
ORGANELLE-SPECIFIC PHARMACEUTICAL NANOTECHNOLOGY......Page 5
CONTENTS......Page 7
PREFACE......Page 11
CONTRIBUTORS......Page 13
CHAPTER 1: An Introduction to Subcellular Nanomedicine: Current Trends and Future Developments......Page 17
CHAPTER 2: Delivery of Nanosensors to Measure the Intracellular Environment......Page 31
CHAPTER 3: Cytoplasmic Diffusion of Dendrimers and Dendriplexes......Page 51
CHAPTER 4: Endocytosis and Intracellular Trafficking of Quantum Dot–Ligand Bioconjugates......Page 71
CHAPTER 5: Synthesis of Metal Nanoparticle-Based Intracellular Biosensors and Therapeutic Agents......Page 89
CHAPTER 6: Subcellular Fate of Nanodelivery Systems......Page 109
CHAPTER 7: Intracellular Fate of Plasmid DNA Polyplexes......Page 139
CHAPTER 8: Intracellular Trafficking of Membrane Receptor-Mediated Uptake of Carbon Nanotubes......Page 159
CHAPTER 9: Real-Time Particle Tracking for Studying Intracellular Transport of Nanotherapeutics......Page 177
CHAPTER 10: Tracking Intracellular Polymer Localization Via Fluorescence Microscopy......Page 193
CHAPTER 11: Can QSAR Models Describing Small-Molecule Xenobiotics Give Useful Tips for Predicting Uptake and Localization of Nanoparticles in Living Cells? And If Not, Why Not?......Page 209
CHAPTER 12: Self-Unpacking Gene Delivery Scaffolds......Page 223
CHAPTER 13: Cellular Trafficking of Dendrimers......Page 247
CHAPTER 14: Endolysosomolytically Active pH-Sensitive Polymeric Nanotechnology......Page 263
CHAPTER 15: Uptake and Intracellular Dynamics of Proteins Internalized by Cell-Penetrating Peptides......Page 279
CHAPTER 16: Cargo Transport by Teams of Molecular Motors: Basic Mechanisms for Intracellular Drug Delivery......Page 305
CHAPTER 17: The Potential of Photochemical Internalization (PCI) for the Cytosolic Delivery of Nanomedicines......Page 327
CHAPTER 18: Peptide-Based Nanocarriers for Intracellular Delivery of Biologically Active Proteins......Page 339
CHAPTER 19: Organelle-Specific Pharmaceutical Nanotechnology: Active Cellular Transport of Submicro- and Nanoscale Particles......Page 353
CHAPTER 20: Subcellular Targeting of Virus-Envelope-Coated Nanoparticles......Page 373
CHAPTER 21: Mitochondria-Targeted Pharmaceutical Nanocarriers......Page 401
CHAPTER 22: Cell-Penetrating Peptides for Cytosolic Delivery of Biomacromolecules......Page 419
CHAPTER 23: Therapeutic Nano-object Delivery to Subdomains of Cardiac Myocytes......Page 449
CHAPTER 24: Design Parameters Modulating Intracellular Drug Delivery: Anchoring to Specific Cellular Epitopes, Carrier Geometry, and Use of Auxiliary Pharmacological Agents......Page 465
CHAPTER 25: Uptake Pathways Dependent Intracellular Trafficking of DNA Carrying Nanodelivery Systems......Page 491
CHAPTER 26: Cellular Interactions of Plasmon-Resonant Gold Nanorods......Page 523
CHAPTER 27: Quantum Dot Labeling for Assessment of Intracellular Trafficking of Therapeutically Active Molecules......Page 551
INDEX......Page 585
