Squamous cell carcinoma of the oral cavity (SCCOC) is one of the most prevalent tumors of the head and neck region. Despite improvements in treatment, the survival of patients with SCCOC has not significantly improved over the past several decades. Most frequently, treatment failure takes the form of local and regional recurrences, but as disease control in these areas improves, SCCOC treatment failures more commonly occur as distant metastasis. This book summarizes the current status of investigations into SCCOC metastases and potential of these studies to positively impact clinical management of SCCOC in the future.
Author(s): Eugene N. Myers (auth.), Jeffrey Myers (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2010
Language: English
Pages: 346
Tags: Cancer Research; Oncology
Front Matter....Pages i-xviii
Oral Cancer Overview: The Significance of Metastasis and Surgical Management of the Neck....Pages 1-32
The Role of Diagnostic Imaging in Identifying Cervical Metastases in Oral Cavity Cancer....Pages 33-48
Sentinel Node Biopsy in Oral Cancer....Pages 49-74
Prediction of Nodal Metastases from Genomic Analyses of the Primary Tumor....Pages 75-103
The Role of High Throughput Molecular Analysis of Biofluids and Tumors in Patients with Oral Cancer....Pages 105-120
Adjuvant Therapy for Patients with Oral Cavity Cancer....Pages 121-134
Animal Models of Oral Cancer Metastasis....Pages 135-161
TGFβ Signaling in Head and Neck Cancer Development and Metastases....Pages 163-183
Growth Factor Receptor Signaling and Metastasis of Oral Cancer....Pages 185-196
Nuclear Transcription Factors and Signaling Pathways in Oral Cancer Metastasis....Pages 197-229
Wnt/β-Catenin Signaling and Oral Cancer Metastasis....Pages 231-264
Role of Tumor Stromal Interactions and Proteases in Oral Cancer Metastasis....Pages 265-286
Chemokines and Their Receptors in Oral Cancer Metastasis....Pages 287-298
Hypoxia, Angiogenesis, and Oral Cancer Metastasis....Pages 299-321
Cancer Stem Cells and Oral Cavity Cancer Metastasis....Pages 323-335
Back Matter....Pages 337-346
