This multi-author contributed volume gives a comprehensive overview of recent progress in various vibrational spectroscopic techniques and chemometric methods and their applications in chemistry, biology and medicine. In order to meet the needs of readers, the book focuses on recent advances in technical development and potential exploitations of the theory, as well as the new applications of vibrational methods to problems of recent general interest that were difficult or even impossible to achieve in the not so distant past. Integrating vibrational spectroscopy and computational approaches serves as a handbook for people performing vibrational spectroscopy followed by chemometric analysis hence both experimental methods as well as procedures of recommended analysis are described. This volume is written for individuals who develop new methodologies and extend these applications to new realms of chemical and medicinal interest.
Author(s): Malgorzata Baranska, Maciej Roman, Katarzyna Majzner (auth.), Malgorzata Baranska (eds.)
Series: Challenges and Advances in Computational Chemistry and Physics 14
Edition: 1
Publisher: Springer Netherlands
Year: 2014
Language: English
Pages: 540
Tags: Theoretical and Computational Chemistry; Medical Biochemistry; Spectroscopy/Spectrometry; Analytical Chemistry
Front Matter....Pages i-xii
Front Matter....Pages 1-1
General Overview on Vibrational Spectroscopy Applied in Biology and Medicine....Pages 3-14
Integrating Optical Spectroscopy and Chemometric Methods....Pages 15-26
Front Matter....Pages 27-27
Surface-enhanced Raman Scattering (SERS) in Bioscience: A Review of Application....Pages 29-59
Raman Optical Activity of Biological Samples....Pages 61-81
α-Amino Acids In Water: A Review Of VCD And ROA Spectra....Pages 83-160
Electronic Circular Dichroism Spectroscopy in Structural Analysis of Biomolecular Systems....Pages 161-177
Biologically Relevant Molecules Studied in Low Temperature Inert Matrices....Pages 179-211
Two-Dimensional Mid-Infrared Correlation Spectroscopy in Protein Research....Pages 213-250
Front Matter....Pages 251-251
Qualitative and Quantitative FT-Raman Analysis of Plants....Pages 253-278
Chemometric Analysis of Raman and IR Spectra of Natural Dyes....Pages 279-308
Structural and Spatial Analysis of Carotenoids in a Single Cell Monitored by Raman Spectroscopy....Pages 309-326
Front Matter....Pages 327-327
Raman Spectra of Solid Amino Acids: Spectral Correlation Analysis as the First Step Towards Identification by Raman Spectroscopy....Pages 329-354
Vibrational Spectroscopy: Disease Diagnostics and Beyond....Pages 355-399
Quantitative Analysis of Disease Biomarkers Using Surface-Enhanced Raman Scattering Spectroscopy....Pages 401-417
FTIR Imaging of Tissues: Techniques and Methods of Analysis....Pages 419-473
Fourier Transform Infrared (Ft-Ir) Spectroscopic Imaging for Solid Tumor Histopathology....Pages 475-504
Vibrational Microspectroscopy for Analysis of Atherosclerotic Arteries....Pages 505-535
Back Matter....Pages 537-540
