Optical Interferometry for Biology and Medicine

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This book presents the fundamental physics of optical interferometry as applied to biophysical, biological and medical research. Interference is at the core of many types of optical detection and is a powerful probe of cellular and tissue structure in interfererence microscopy and in optical coherence tomography. It is also the root cause of speckle and other imaging artefacts that limit range and resolution. For biosensor applications, the inherent sensitivity of interferometry enables ultrasensitive detection of molecules in biological samples for medical diagnostics. In this book, emphasis is placed on the physics of light scattering, beginning with the molecular origins of refraction as light propagates through matter, and then treating the stochastic nature of random fields that ultimately dominate optical imaging in cells and tissue. The physics of partial coherence plays a central role in the text, with a focus on coherence detection techniques that allow information to be selectively detected out of incoherent and heterogeneous backgrounds.

Optical Interferometry for Biology and Medicine is divided into four sections. The first covers fundamental principles, and the next three move up successive scales, beginning with molecular interferometry (biosensors), moving to cellular interferometry (microscopy), and ending with tissue interferometry (biomedical). An outstanding feature of the book is the clear presentation of the physics, with easy derivations of the appropriate equations, while emphasizing "rules of thumb" that can be applied by experimental researchers to give semi-quantitative predictions.

Author(s): David D. Nolte (auth.)
Series: Bioanalysis 1
Edition: 1
Publisher: Springer-Verlag New York
Year: 2012

Language: English
Pages: 354
Tags: Biophysics and Biological Physics;Biomedical Engineering;Optics, Optoelectronics, Plasmonics and Optical Devices;Molecular Medicine

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Interferometry....Pages 3-48
Diffraction and Light Scattering....Pages 49-94
Speckle and Spatial Coherence....Pages 95-121
Surface Optics....Pages 123-145
Front Matter....Pages 147-147
Interferometric Thin-Film Optical Biosensors....Pages 149-175
Diffraction-Based Interferometric Biosensors....Pages 177-195
Interferometric Waveguide Sensors....Pages 197-223
Front Matter....Pages 225-225
Cell Structure and Dynamics....Pages 227-249
Interference Microscopy....Pages 251-272
Front Matter....Pages 273-273
Light Propagation in Tissue....Pages 275-296
Optical Coherence Tomography....Pages 297-306
Holography of Tissues....Pages 307-333
Appendix: Mathematical Formulas....Pages 335-341
Back Matter....Pages 343-354