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Ocular neuroprotection

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Many retinal and optic nerve disorders have no effective therapy, or are treated incompletely and with considerable side effects. Recent advances have suggested the significant benefits associated with neuroprotection-that is, when treatment strategies are directed to photoreceptors, retinal ganglion cells, or other neural targets. This book is the only handbook of research methods in neuroprotection of ocular  Read more...

Author(s): Leonard A. Levin, Adriana Di Polo
Publisher: Marcel Dekker
Year: 2003

Language: English
Pages: 322
City: New York

I. In vitro models / James D. Lindsey --
1. Culture of retinal neurons --
II. In vivo models of optic nerve damage --
2. Crush injury of the optic nerve / Michal Schwartz and Eti Yoles --
3. Intraocular pressure elevation: vein cauterization / Sansar C. Sharma --
4. Intraocular pressure elevation: injecting hypertonic saline into episcleral veins / John C. Morrison, Elaine C. Johnson, Lijun Jia, and William O. Cepurna --
5. Intraocular pressure elevation: laser photocoagulation of the trebecular meshwork / B'Ann T. Gabelt, James N. Ver Hoeve, and Paul L. Kaufman --
III. In vivo models of retinal damage --
6. Light-induced retinal degeneration / Daniel T. Organisciak, R.M. Darrow, and L.S. Barsalou --
7. Retinal degeneration / Ward M. Peterson --
8. Retinal ischemia / Manuel Vidal-Sanz et al --
IV. Neuroprotective strategies --
9. Drug delivery / Robert W. Nickells and Cassandra L. Schlamp --
10. Recombinant viral vectors / Przemyslaw Sapieha and Adriana Di Polo --
V. Analysis of neuronal survival and function --
11. Quantification of retinal cells / Christine A. Curcio and Kenneth R. Sloan --
12. Ex vivo and whole-mount retinal preparations / Arthur J. Weber --
13. Detection of single-cell apoptosis / William G. Tatton, Ruth M.E. Chalmers-Redman, and Nadine A. Tatton --
14. Imaging of retinal ganglion cells / Joshua P. Vrabec and Leonard A. Levin --
15. Evaluation of retinal function: electroretinography / Marc HeĢbert and Pierre Lachapelle --
VI. Clinical trials --
16. Evaluation of visual outcome / Pamela A. Sample --
17. Clinical trials in neuroprotection / Scott M. Whitcup --
18. Regulatory issues in clinical trials / Anthony C. Arnold --
Index.