Chemoprevention of cancer has been the focus of intensive research for more than two decades. Epidemiological evidence has shown a small, but significant association between fruit and vegetable intake and a reduction in cancer risk. Diet may account for about thirty five percent of cancer. Large claims have been made for the effectiveness of particular diets in determining one's risk of developing cancer, ranging from protection against cancer initiation, progression and metastasis. A wide array of dietary components has been demonstrated to be as effective in fighting off cancer. Towards an increased understanding of the nutrition, excercise and diet in preventing cancer or inhibiting its progression has led to the discovery and development of novel and effective drugs that regulate intracellular signaling network in the body. This information will be very useful to explore novel and highly effective chemopreventive strategies for reducing the health burden of cancer. Hippocrates, who proclaimed 25 centuries ago, 'Let food be thy medicine and medicine be thy food'. They estimated that one third of all cancer cases could be prevented by a healthier diet; statements which are widely accepted in the scientific literature. This book covers the current state-of-the art knowledge on the impact of nutrition and diet with nutrigenetics, nutritional epigenomics, nutritional transcriptomics, proteomics, and metabolomics approach in cancer prevention and therapy.
Author(s): Ramamurthi Vidya Priyadarsini, Siddavaram Nagini (auth.), Sharmila Shankar, Rakesh K. Srivastava (eds.)
Edition: 1
Publisher: Springer Netherlands
Year: 2012
Language: English
Pages: 628
Tags: Biomedicine general; Cancer Research; Nutrition
Front Matter....Pages i-xv
Aberrant Signaling Pathways in Cancer: Modulation by the Dietary Flavonoid, Quercetin....Pages 1-21
Micronutrients and Cancer: Add Spice to Your Life....Pages 23-48
Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics....Pages 49-81
Molecular Insight and Preclinical Perspective of Thymoquinone as Chemopreventive Agent and Therapeutic Adjunct in Cancer....Pages 83-107
Dietary Biofactors in the Management of Cancer: Myth or Reality?....Pages 109-127
Nutritional Compounds as Chemopreventive Agents by Proteasome Inhibition....Pages 129-148
STAT Signaling in Cancer Prevention....Pages 149-167
γδ T Cells, Tea and Cancer....Pages 169-184
Phytochemical Intakes with a Mediterranean Diet: Levels Achievable with an Exchange List Diet and Potential Biomarkers in Blood....Pages 185-208
Plant Polyphenols and Their Role in Cancer Prevention and Chemotherapy....Pages 209-234
Role of Food Micro-molecules in the Prevention of Cancer....Pages 235-253
The Protective Role of Zinc in Cancer: A Potential Chemopreventive Agent....Pages 255-282
Diet-Induced Epigenetic Changes and Cancer Prevention: A Mantra for Healthy Living....Pages 283-326
Western Diet-Induced Pancreatic Cancer....Pages 327-338
Intracellular Signaling Network as a Prime Chemotherapy Target of Green Tea Catechin, (–)-Epigallocatechin-3-gallate....Pages 339-376
Role of Dietary Antioxidants in Cancer....Pages 377-412
Curcumin: Structure, Biology and Clinical Applications....Pages 413-457
Obesity, Cancer and Psychopathology: Can Vegetarian Diet Be of Help?....Pages 459-491
Dietary Phytochemicals as Epigenetic Modulators in Cancer....Pages 493-519
Modulation of the Nrf2 Signaling Pathway by Chemopreventive Dietary Phytoconstituents....Pages 521-539
Role of Fish Oil from Gene Expression to Pharmacological Effect in Cancer Prevention....Pages 541-555
Antioxidant Supplements: An Evidence-Based Approach to Health Benefits and Risks....Pages 557-561
Natural Antioxidants and Their Role in Cancer Prevention....Pages 563-583
Dietary and Non-dietary Phytochemicals in Cancer Control....Pages 585-622
Back Matter....Pages 623-627
