Nucleic Acid Nanotechnology

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This volume on nucleic acid nanotechnology offers authoritative, up-to-date and comprehensive coverage of nanotechnological studies and applications of nucleic acids. It provides reviews of various aspects of nucleic acid nanotechnology, each written by an internationally leading expert in the field, and presents state-of-the-art and recent advances in nucleic acid synthetic modifications, nanoscale design, manipulation and current and future applications in bioengineering, medicine, electronics, genetic analysis, chemistry, molecular biology, surface and material sciences. It examines how nucleic acid research is merging with nanotechnology, allowing the nanoscale properties of nucleic acid to be exploited in performing challenging nanotechnological tasks, from nanorobotics and nanosensing to nucleic acid computing. This book will above all benefit anyone who is interested in nanotechnological concepts of nucleic acid design and applications, and offers a valuable resource for teaching these concepts. It is essential reading for a broad audience of scientists both in academia and industry who wish to expand their expertise on the potential of nucleic acid functions and applications.

Author(s): Lei Liu, Flemming Besenbacher, MingDong Dong (auth.), Jørgen Kjems, Elena Ferapontova, Kurt V. Gothelf (eds.)
Series: Nucleic Acids and Molecular Biology 29
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2014

Language: English
Pages: 339
Tags: Nucleic Acid Chemistry; Nanochemistry; Gene Expression; Bioinformatics; Cell Biology

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Self-Assembly of DNA Bases via Hydrogen Bonding Studied by Scanning Tunneling Microscopy....Pages 3-21
Force Spectroscopy of DNA and RNA: Structure and Kinetics from Single-Molecule Experiments....Pages 23-52
The Power of Single-Molecule FRET Microscopy Applied to DNA Nanotechnology....Pages 53-68
Front Matter....Pages 69-69
Tile-Based DNA Nano-assemblies....Pages 71-92
DNA Origami....Pages 93-133
DNA Nanotechnology: From Biology and Beyond....Pages 135-169
Front Matter....Pages 171-171
DNA-Templated Synthesis....Pages 173-197
Front Matter....Pages 199-199
Mechanical DNA Devices....Pages 201-242
Front Matter....Pages 243-243
Nano-encapsulation of Oligonucleotides for Therapeutic Use....Pages 245-260
Cell-Specific Aptamers for Nano-medical Applications....Pages 261-283
Front Matter....Pages 285-285
Nucleic Acid Sequencing and Analysis with Nanopores....Pages 287-303
Application of Nanomaterials for DNA Sensing....Pages 305-332
Back Matter....Pages 333-339